Chromosome 11 Open Reading Frame 30 (C11orf30) antibody

Details for Product No. ABIN649687
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Antigen
Synonyms 2210018M11RIK, EMSY, 2310016L09Rik, AU019521, AU019557, Emsy, emsy, fj36b04, wu:fj36b04
Reactivity
Human, Rat (Rattus)
(29), (12), (12), (12), (12)
Host
Rabbit
(27), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(19), (10), (9), (5), (3), (1), (1)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN649687
450.00 $
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Specificity A synthetic peptide corresponding to residues near the C-term of human EMSY isoform 1 was used as immunogen.
Alternative Name EMSY
Background EMSY is a novel protein whose sequence is found in a chromosomal region known to be involved in breast and ovarian cancer (1). The N-terminus of EMSY binds BRCA2 (exon 3). EMSY is capable of silencing the exon 3 encoded transcrip-tional activation domain of BRCA2. EMSY, just like BRCA2, is located in the nucleus and functions with DNA repair and transcriptional regulation factors (2). EMSY was found to be overactive in 13% of sporadic cases of breast cancer and 17% of ovarian cancers and it was also linked with poor survival, specifically in node-negative breast cancer, suggesting that it may be of prognostic value (1).
Synonyms: EMSY, C11orf30, Protein EMSY
Molecular Weight 150 kDA
Gene ID 56946
UniProt Q7Z589
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:2000-5000
Comment

Background: EMSY is a novel protein whose sequence is found in a chromosomal region known to be involved in breast and ovarian cancer (1). The N-terminus of EMSY binds BRCA2 (exon 3). EMSY is capable of silencing the exon 3 encoded transcrip-tional activation domain of BRCA2. EMSY, just like BRCA2, is located in the nucleus and functions with DNA repair and transcriptional regulation factors (2). EMSY was found to be overactive in 13% of sporadic cases of breast cancer and 17% of ovarian cancers and it was also linked with poor survival, specifically in node-negative breast cancer, suggesting that it may be of prognostic value (1).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment EMSY Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Hughes-Davies, Huntsman, Ruas et al.: "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer." in: Cell, Vol. 115, Issue 5, pp. 523-35, 2003 (PubMed).

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