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Details for Product No. ABIN649691

Endonuclease G (ENDOG) (C-Term) antibody

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Antigen
Synonyms wu:fb79c08, zgc:110020, CG8862, Dmel\\CG8862, Tb08.10J17.140, Tb08.10J17.90, TBC1D13, endog, ENDOG
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN649691
Quantity 100 µL
Price
392.86 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues on the C-terminus of human Endo G was used as an immunogen.
Alternative Name Endo G
Background Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to the nucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatin DNA into nucleosomal fragments independently of caspases. Therefore, endoG represents a caspase-independent apoptotic pathway initiated from the mitochondria (1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported to be important for both nuclear DNA fragmentation during apoptosis and mitochondrial DNA replication. Findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation (2).
Synonyms: ENDOG, Endonuclease G, mitochondrial
Molecular Weight 35 kDA
Gene ID 2021
UniProt Q14249
Research Area Cell Signaling, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:2000~5000
Comment

Background: Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to the nucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatin DNA into nucleosomal fragments independently of caspases. Therefore, endoG represents a caspase-independent apoptotic pathway initiated from the mitochondria (1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported to be important for both nuclear DNA fragmentation during apoptosis and mitochondrial DNA replication. Findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Endo G Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Li, Luo, Wang: "Endonuclease G is an apoptotic DNase when released from mitochondria." in: Nature, Vol. 412, Issue 6842, pp. 95-9, 2001 (PubMed).

Zhang, Dong, Li et al.: "Endonuclease G is required for early embryogenesis and normal apoptosis in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 15782-7, 2003 (PubMed).

Alternatives for antigen "Endonuclease G (ENDOG)", type "Antibodies"
Hosts (55), (41)
Reactivities (91), (57), (53), (13), (13), (12), (12), (1), (1)
Applications (86), (37), (12), (10), (10), (8), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (7), (6), (5), (4), (3), (3), (2), (1), (1)
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