|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Mitogen-Activated Protein Kinase 1 (MAPK1) (C-Term) antibody
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
|2 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||Erk2/p42 MAPK|
|Description||Other names: MAPK1, ERK2, PRKM1, PRKM2, Mitogen-activated protein kinase 1, p42-MAPK,ERT1|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues near the C-term of human ERK2 p42 MAPK was used as immunogen.|
|Molecular Weight||42 kDA|
Background: Extracellular signal regulated kinase 2 (ERK 2) also known as maturation or mitogen activated protein kinase (MAPK) is involved in eukaryotic signal transduction (1) . Activated by a dual phosphorylation on threonine and tyrosine residue by the dual-specificity kinase MKK1/2, ERK2 p42 translocate to the nucleus after stimulation (2). Once phosphorylated, ERK2 can form dimers with phosphorylated and unphosphorylated ERK2 partners. It is also able to phosphorylate multiple substrates such as EGFR, c-PLA2, Elk1/TCF and c-Myc (3-5).
|Synonyms||ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, ERK3, PRKM6, p97MAPK, HsT17250, DKFZp686F03189, Erk2, Prkm1, C78273, p42mapk, AA407128, AU018647, 9030612K14Rik, zERK2, MAPK1, Xp42, erk, erk2, mapk, mpk1, xp42, mapk1a, MGC68934, ert1, mapk2, prkm1, prkm2, F14N23.9, F14N23_9, MITOGEN-ACTIVATED PROTEIN KINASE, MITOGEN-ACTIVATED PROTEIN KINASE 1, MPK1|
|Application Notes||The suggested dilution is: WB: ~~ 1:1000~5000 IP: ~~ 1:20 FC: ~~ 1:60 ICC: ~~ 1:100~250 IHC: ~~ 1:250~500|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Erk2/p42 MAPK Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Translation Factors, Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Seth, Gonzalez, Gupta et al.: "Signal transduction within the nucleus by mitogen-activated protein kinase." in: The Journal of biological chemistry, Vol. 267, Issue 34, pp. 24796-804, 1992 (PubMed).
Lin, Wartmann, Lin et al.: "cPLA2 is phosphorylated and activated by MAP kinase." in: Cell, Vol. 72, Issue 2, pp. 269-78, 1993 (PubMed).