anti-ERK2 antibody (Mitogen-Activated Protein Kinase 1) (C-Term)

Details for Product anti-MAPK1 Antibody No. ABIN649710
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Antigen
Epitope
C-Term
(63), (21), (18), (9), (9), (9), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(251), (80), (66), (6), (6), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(158), (99), (17), (4), (2)
Clonality
Monoclonal
Conjugate
This ERK2 antibody is un-conjugated
(6), (4), (4), (4), (3), (3), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(244), (107), (76), (50), (47), (42), (14), (12), (11), (6), (5), (3), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
Options
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Specificity A synthetic peptide corresponding to residues near the C-term of human ERK2 p42 MAPK was used as immunogen.
Alternative Name Erk2/p42 MAPK (MAPK1 Antibody Abstract)
Background Extracellular signal regulated kinase 2 (ERK 2) also known as maturation or mitogen activated protein kinase (MAPK) is involved in eukaryotic signal transduction (1) . Activated by a dual phosphorylation on threonine and tyrosine residue by the dual-specificity kinase MKK1/2, ERK2 p42 translocate to the nucleus after stimulation (2). Once phosphorylated, ERK2 can form dimers with phosphorylated and unphosphorylated ERK2 partners. It is also able to phosphorylate multiple substrates such as EGFR, c-PLA2, Elk1/TCF and c-Myc (3-5).
Synonyms: MAPK1, ERK2, PRKM1, PRKM2, Mitogen-activated protein kinase 1, p42-MAPK,ERT1
Molecular Weight 42 kDA
Gene ID 5594
UniProt P28482
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Pathways MAPK Pathway
Application Notes IHC: = 1:250-500, WB: = 1:1000-5000
Comment

Background: Extracellular signal regulated kinase 2 (ERK 2) also known as maturation or mitogen activated protein kinase (MAPK) is involved in eukaryotic signal transduction (1) . Activated by a dual phosphorylation on threonine and tyrosine residue by the dual-specificity kinase MKK1/2, ERK2 p42 translocate to the nucleus after stimulation (2). Once phosphorylated, ERK2 can form dimers with phosphorylated and unphosphorylated ERK2 partners. It is also able to phosphorylate multiple substrates such as EGFR, c-PLA2, Elk1/TCF and c-Myc (3-5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Erk2/p42 MAPK Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lin, Wartmann, Lin et al.: "cPLA2 is phosphorylated and activated by MAP kinase." in: Cell, Vol. 72, Issue 2, pp. 269-78, 1993 (PubMed).

Seth, Gonzalez, Gupta et al.: "Signal transduction within the nucleus by mitogen-activated protein kinase." in: The Journal of biological chemistry, Vol. 267, Issue 34, pp. 24796-804, 1992 (PubMed).

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Catalog No. ABIN649710
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