Fibroblast Growth Factor 1 (Acidic) (FGF1) (C-Term) antibody

Details for Product No. ABIN649743
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Antigen
Synonyms
FGF1, zgc:136885, aFGF, ecgf, fgfa, ecgfa, ecgfb, fgf-1, hbgf1, HBGF-1, glio703, ecgf-beta, fgf-alpha, LOC100221393, FGF-1, Fgf1, Dffrx, Fam, Fgf-1, Fgfa, ECGF, AFGF, ECGF-beta, ECGFA, ECGFB, FGF-alph ... show more
FGF1, zgc:136885, aFGF, ecgf, fgfa, ecgfa, ecgfb, fgf-1, hbgf1, HBGF-1, glio703, ecgf-beta, fgf-alpha, LOC100221393, FGF-1, Fgf1, Dffrx, Fam, Fgf-1, Fgfa, ECGF, AFGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1 show less
Epitope
C-Term
(15), (10), (7), (6), (6), (4), (1), (1), (1), (1), (1)
Reactivity
Human
(112), (48), (30), (5), (1), (1)
Host
Rabbit
(108), (27)
Clonality
Monoclonal
Conjugate
Un-conjugated
(9), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(98), (68), (23), (22), (17), (13), (10), (7), (7), (6), (6), (5), (5), (4), (2), (2), (1)
Pubmed 4 references available
Quantity 100 μL
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Catalog No. ABIN649743
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human FGFR1 was used as an immunogen.
Alternative Name FGF-1
Background Fibroblast growth factors (FGFs) are polypeptide mitogens that induce the proliferation of a wide variety of cell types (1). Fibroblast growth factor (FGF)/FGF receptor (FGFR1) signaling plays a crucial role in mesoderm formation and patterning. Studies suggest that FGFR1, among the different FGFRs, may play a role in cardiogenesis. Data point to a nonredundant role for FGFR1-mediated signaling in cardiomyocyte development (2). It has also been shown that during development, FGFR1 is required for the generation of the precursor pool, which gives rise to the auditory sensory epithelium. Data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium (3). Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes. Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing. These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing (4).
Synonyms: FGFR1, FGFBR, FLG, FLT2, Basic fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2,c-fgr
Molecular Weight 130 kDA
Gene ID 2260
UniProt P11362
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes The suggested dilution is: WB: = 1:500
Comment

Background: Fibroblast growth factors (FGFs) are polypeptide mitogens that induce the proliferation of a wide variety of cell types (1). Fibroblast growth factor (FGF)/FGF receptor (FGFR1) signaling plays a crucial role in mesoderm formation and patterning. Studies suggest that FGFR1, among the different FGFRs, may play a role in cardiogenesis. Data point to a nonredundant role for FGFR1-mediated signaling in cardiomyocyte development (2). It has also been shown that during development, FGFR1 is required for the generation of the precursor pool, which gives rise to the auditory sensory epithelium. Data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium (3). Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes. Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing. These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment FGF-1 Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Eisemann, Ahn, Graziani et al.: "Alternative splicing generates at least five different isoforms of the human basic-FGF receptor." in: Oncogene, Vol. 6, Issue 7, pp. 1195-202, 1991 (PubMed).

Plotnikov, Hubbard, Schlessinger et al.: "Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity." in: Cell, Vol. 101, Issue 4, pp. 413-24, 2000 (PubMed).

Pirvola, Ylikoski, Trokovic et al.: "FGFR1 is required for the development of the auditory sensory epithelium." in: Neuron, Vol. 35, Issue 4, pp. 671-80, 2002 (PubMed).

DellEra, Ronca, Coco et al.: "Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development." in: Circulation research, Vol. 93, Issue 5, pp. 414-20, 2003 (PubMed).

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