Fibroblast Growth Factor 2 (Basic) (FGF2) antibody

Details for Product No. ABIN649744
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Antigen
Synonyms BFGF, FGF-2, HBGF-2, FGFB, Fgfb, bFGF, Fgf-2, bfgf, fgf-2, fgfb, hbgh-2, xfgf2, HBGF2, LOC100227798
Reactivity
Human
(172), (40), (37), (32), (16), (4), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(105), (94), (4), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(16), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(133), (116), (49), (36), (18), (18), (11), (10), (10), (10), (10), (9), (7), (2), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN649744
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues in human FGF2 was used as an immunogen.
Alternative Name FGF2
Background Basic fibroblast growth factor (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary. FGF2 has been implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumor growth (1). It is also an important modulator of cartilage and bone growth and differentiation (2). FGF2 consists of multiple protein isoforms produced by alternative translation from the FGF2 gene. High molecular weight FGF2 isoforms are not secreted from the cell, but are transported to the nucleus where they regulate cell growth or behavior in an intracrine fashion. 18 kDa FGF2 can be secreted to the extracellular medium where it acts as a conventional growth factor by binding to and activation of cell-surface receptors (3, 4). These protein isoforms are localized to different cellular compartments, indicating unique biological activity. FGF2 isoforms in the heart have distinct roles in many pathological circumstances in the heart including cardiac hypertrophy, ischemia-reperfusion injury, and atherosclerosis (4).
Molecular Weight 18, 21, 24 kDA
Gene ID 2247
UniProt P09038
Research Area Cell Cycle, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000
Comment

Background: Basic fibroblast growth factor (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary. FGF2 has been implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumor growth (1). It is also an important modulator of cartilage and bone growth and differentiation (2). FGF2 consists of multiple protein isoforms produced by alternative translation from the FGF2 gene. High molecular weight FGF2 isoforms are not secreted from the cell, but are transported to the nucleus where they regulate cell growth or behavior in an intracrine fashion. 18 kDa FGF2 can be secreted to the extracellular medium where it acts as a conventional growth factor by binding to and activation of cell-surface receptors (3, 4). These protein isoforms are localized to different cellular compartments, indicating unique biological activity. FGF2 isoforms in the heart have distinct roles in many pathological circumstances in the heart including cardiac hypertrophy, ischemia-reperfusion injury, and atherosclerosis (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment FGF2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Montero, Okada, Tomita et al.: "Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation." in: The Journal of clinical investigation, Vol. 105, Issue 8, pp. 1085-93, 2000 (PubMed).

Hamosh, Scott, Amberger et al.: "Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders." in: Nucleic acids research, Vol. 33, Issue Database issue, pp. D514-7, 2004 (PubMed).

Sørensen, Nilsen, Wiedłocha: "Functional diversity of FGF-2 isoforms by intracellular sorting." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 28, Issue 5, pp. 504-14, 2006 (PubMed).

Liao, Bodmer, Pietras et al.: "Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 238, Issue 2, pp. 249-64, 2009 (PubMed).

Hosts (105), (94), (4), (2), (1)
Reactivities (172), (40), (37), (32), (16), (4), (2), (2), (1), (1), (1), (1)
Applications (133), (116), (49), (36), (18), (18), (11), (10), (10), (10), (10), (9), (7), (2), (2), (2), (1), (1), (1), (1)
Conjugates (16), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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