FK506 Binding Protein 6, 36kDa (FKBP6) antibody

Antigen: FK506 Binding Protein 6, 36kDa (FKBP6)

Synonyms: FKBP36, PPIase, MGC87179, 36kDa, FKBP-6, AU017274, D5Ertd724e, 1700008G22Rik

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Certificates: ISO 9001:2008

Catalog no.: ABIN649758

Additional Information

Alternative name: FKBP6

Gene ID: 328

UniProt: O75344

Characteristics: Rabbit Monoclonal IgG

Specificity: A synthetic peptide corresponding to residues near the C-terminus in human FKBP6 was used as an immunogen.

Molecular Weight: 38 kDA

Comments:

Background: FK506 binding protein 6 (FKBP6) is a cellular receptor for the immunosuppressants FK506 and rapamycin in the immunophilin FKBP family (1). FKBP's are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription (2). It forms a complex as FKBP-FK506 to competitively bind to and inhibit the Calcium- and calmodulin-dependent phosphatase calcineurin (3). FKBP6 plays a role in sex-specific fertility as a component of the synaptonemal complex, which is essential for chromosome pairing and meiotic division (4). A genetic deletion in FKBP6 is associated with Williams-Beuren syndrome (WBS), a neurodevelopmental disorder (5).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~10000 FC: ~~ 1 : 10~100 IHC: ~~ 1 : 100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: FKBP6 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Translation Factors, Protein Modifications, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Liu, Farmer, Lane et al.: "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes." in: Cell, Vol. 66, Issue 4, pp. 807-15, 1991 (PubMed).

Crackower, Kolas, Noguchi et al.: "Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis." in: Science (New York, N.Y.), Vol. 300, Issue 5623, pp. 1291-5, 2003 (PubMed).

Metcalfe, Simeonov, Beckett et al.: "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6." in: Clinical dysmorphology, Vol. 14, Issue 2, pp. 61-5, 2005 (PubMed).

Kang, Hong, Dhe-Paganon et al.: "FKBP family proteins: immunophilins with versatile biological functions." in: Neuro-Signals, Vol. 16, Issue 4, pp. 318-25, 2008 (PubMed).

Bichet: "V2R mutations and nephrogenic diabetes insipidus." in: Progress in molecular biology and translational science, Vol. 89, pp. 15-29, 2010 (PubMed).