FK506 Binding Protein 6, 36kDa (FKBP6) antibody

Details for Product No. ABIN649758
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Antigen
Synonyms FKBP36, 1700008G22Rik, 36kDa, AU017274, D5Ertd724e, FKBP-36, FKBP-6, PPiase
Reactivity
Human, Rat (Rattus)
(22), (16), (16), (13), (13), (12), (12), (1)
Host
Rabbit
(20), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(13), (10), (8), (6), (3), (1)
Pubmed 5 references available
Catalog no. ABIN649758
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Specificity A synthetic peptide corresponding to residues near the C-terminus in human FKBP6 was used as an immunogen.
Alternative Name FKBP6
Background FK506 binding protein 6 (FKBP6) is a cellular receptor for the immunosuppressants FK506 and rapamycin in the immunophilin FKBP family (1). FKBP's are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription (2). It forms a complex as FKBP-FK506 to competitively bind to and inhibit the Calcium- and calmodulin-dependent phosphatase calcineurin (3). FKBP6 plays a role in sex-specific fertility as a component of the synaptonemal complex, which is essential for chromosome pairing and meiotic division (4). A genetic deletion in FKBP6 is associated with Williams-Beuren syndrome (WBS), a neurodevelopmental disorder (5).
Molecular Weight 38 kDA
Gene ID 328
UniProt O75344
Research Area Translation Factors, Protein Modifications, Signaling, Cell Structure
Application Notes IHC: = 1 : 100-250, WB: = 1:1000-10000
Comment

Background: FK506 binding protein 6 (FKBP6) is a cellular receptor for the immunosuppressants FK506 and rapamycin in the immunophilin FKBP family (1). FKBP's are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription (2). It forms a complex as FKBP-FK506 to competitively bind to and inhibit the Calcium- and calmodulin-dependent phosphatase calcineurin (3). FKBP6 plays a role in sex-specific fertility as a component of the synaptonemal complex, which is essential for chromosome pairing and meiotic division (4). A genetic deletion in FKBP6 is associated with Williams-Beuren syndrome (WBS), a neurodevelopmental disorder (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment FKBP6 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Liu, Farmer, Lane et al.: "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes." in: Cell, Vol. 66, Issue 4, pp. 807-15, 1991 (PubMed).

Crackower, Kolas, Noguchi et al.: "Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis." in: Science (New York, N.Y.), Vol. 300, Issue 5623, pp. 1291-5, 2003 (PubMed).

Metcalfe, Simeonov, Beckett et al.: "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6." in: Clinical dysmorphology, Vol. 14, Issue 2, pp. 61-5, 2005 (PubMed).

Kang, Hong, Dhe-Paganon et al.: "FKBP family proteins: immunophilins with versatile biological functions." in: Neuro-Signals, Vol. 16, Issue 4, pp. 318-25, 2008 (PubMed).

Bichet: "V2R mutations and nephrogenic diabetes insipidus." in: Progress in molecular biology and translational science, Vol. 89, pp. 15-29, 2010 (PubMed).

Hosts (20), (3)
Reactivities (22), (16), (16), (13), (13), (12), (12), (1)
Applications (13), (10), (8), (6), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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