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Details for Product No. ABIN649767

GRB2-Associated Binding Protein 2 (GAB2) antibody

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Antigen
Synonyms AI463667, D130058I17Rik, p97, GAB2
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 4 references available
Catalog no. ABIN649767
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in human Gab2 was used as immunogen. This antibody is predicted to detect the splice isoform 2 based on sequence homology.
Alternative Name Gab2
Background Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors, Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).
Synonyms: GAB2, KIAA0571, GRB2-associated-binding protein 2, Growth factor receptor bound protein 2-associated protein 2,GRB2-associated binder 2,pp100
Molecular Weight 97 kDA
Gene ID 9846
UniProt Q9UQC2
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 FC: ~~ 1:20 ICC: ~~ 1:50
Comment

Background: Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors, Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Gab2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Weiss, Littman: "Signal transduction by lymphocyte antigen receptors." in: Cell, Vol. 76, Issue 2, pp. 263-74, 1994 (PubMed).

Holgado-Madruga, Moscatello, Emlet et al.: "Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 23, pp. 12419-24, 1997 (PubMed).

Nishida, Yoshida, Itoh et al.: "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors." in: Blood, Vol. 93, Issue 6, pp. 1809-16, 1999 (PubMed).

Zhao, Yu, Shen et al.: "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19649-54, 1999 (PubMed).

Alternatives for antigen "GRB2-Associated Binding Protein 2 (GAB2)", type "Antibodies"
Hosts (111), (6), (1)
Reactivities (116), (103), (103), (65), (53), (31), (24)
Applications (67), (53), (50), (19), (17), (16), (2), (2), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1), (1), (1)
Epitopes (29), (15), (12), (8), (8), (5), (2), (1), (1), (1), (1)
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