gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) antibody

Details for Product No. ABIN649768
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Antigen
Synonyms Gpr51, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, Gb2, Gm425, GABA(B)R2, si:dkey-190l1.2
Reactivity
Human, Rat (Rattus)
(94), (90), (65), (42), (41), (30), (24), (12), (5), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(98), (29), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(90), (44), (40), (27), (21), (16), (11), (4), (1)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN649768
450.00 $
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human GABA(B) R2 was used as an immunogen.
Alternative Name GABA (B) R2
Background GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. Results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2 (1). Identification of a functional homomeric GABABR2 coupled to adenylyl cyclase suggests that the complexity of GABAB pharmacological data is at least in part due to the presence of more than one receptor and opens avenues for future research leading to an understanding of metabotropic GABA receptor signal transduction mechanisms (2). The activity of GABA(B) R2 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis (3).
Molecular Weight 105 kDA
Gene ID 9568
UniProt O75899
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Neurology
Application Notes IHC: = 1:100, WB: = 1:1000
Comment

Background: GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. Results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2 (1). Identification of a functional homomeric GABABR2 coupled to adenylyl cyclase suggests that the complexity of GABAB pharmacological data is at least in part due to the presence of more than one receptor and opens avenues for future research leading to an understanding of metabotropic GABA receptor signal transduction mechanisms (2). The activity of GABA(B) R2 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment GABA(B) R2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications White, Wise, Main et al.: "Heterodimerization is required for the formation of a functional GABA(B) receptor." in: Nature, Vol. 396, Issue 6712, pp. 679-82, 1999 (PubMed).

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