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gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (pSer884) antibody

Details for Product No. ABIN649769
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Antigen
Synonyms Gpr51, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, Gb2, Gm425, GABA(B)R2, si:dkey-190l1.2
Epitope
pSer884
(20), (20), (17), (12), (10), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(95), (90), (65), (42), (41), (30), (24), (12), (4), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(98), (29), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(90), (45), (40), (27), (21), (16), (11), (4), (1)
Pubmed 2 references available
Quantity 100 µL
Options
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Catalog No. ABIN649769
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Specificity A phospho-specific peptide corresponding residues surrounding serine 884 of human GABAB R2 was used as an immunogen. This antibody detects GABAB R2 phosphorylated at serine 884.
Alternative Name GABA (B) R2
Background GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. Results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2 (1). Identification of a functional homomeric GABABR2 coupled to adenylyl cyclase suggests that the complexity of GABAB pharmacological data is at least in part due to the presence of more than one receptor and opens avenues for future research leading to an understanding of metabotropic GABA receptor signal transduction mechanisms (2). Results support a model in which GABA(B)R2 phosphorylation specifically stabilizes surface GABA(B) receptors in neurons. We propose that signaling pathways that regulate cAMP levels in neurons may have profound effects on the tonic synaptic inhibition by modulating the availability of GABA(B) receptors (3)
Molecular Weight 105 kDA
Gene ID 9568
UniProt O75899
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Neurology
Application Notes The suggested dilution is: WB: = 1:50000-100000
Comment

Background: GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. Results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2 (1). Identification of a functional homomeric GABABR2 coupled to adenylyl cyclase suggests that the complexity of GABAB pharmacological data is at least in part due to the presence of more than one receptor and opens avenues for future research leading to an understanding of metabotropic GABA receptor signal transduction mechanisms (2). Results support a model in which GABA(B)R2 phosphorylation specifically stabilizes surface GABA(B) receptors in neurons. We propose that signaling pathways that regulate cAMP levels in neurons may have profound effects on the tonic synaptic inhibition by modulating the availability of GABA(B) receptors (3)

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment GABA(B) R2 Antibody Phospho (pS884) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications White, Wise, Main et al.: "Heterodimerization is required for the formation of a functional GABA(B) receptor." in: Nature, Vol. 396, Issue 6712, pp. 679-82, 1999 (PubMed).

Fairfax, Pitcher, Scott et al.: "Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12565-73, 2004 (PubMed).

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