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Details for Product No. ABIN649770

gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (pSer893) antibody

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Antigen
Synonyms GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, GABA(B)R2, Gpr51, Gb2, Gm425, si:dkey-190l1.2
Epitope
»Alternatives pSer893
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Pubmed 1 reference available
Catalog no. ABIN649770
Quantity 100 µL
Price
507.14 $   Plus shipping costs $45.00
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Specificity A phospho specific peptide corresponding to residues surrounding serine 893 of human GABA(B) R2 was used as an immunogen. This antibody detects GABA(B) R2 phosphorylated on serine 893.
Alternative Name GABA (B) R2
Background GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. Results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2 (1). Identification of a functional homomeric GABABR2 coupled to adenylyl cyclase suggests that the complexity of GABAB pharmacological data is at least in part due to the presence of more than one receptor and opens avenues for future research leading to an understanding of metabotropic GABA receptor signal transduction mechanisms (2). The activity of GABA(B) R2 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis (3).
Molecular Weight 105 kDA
Gene ID 9568
UniProt O75899
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:10~100 ICC: ~~ 1:100 IHC: ~~ 1:100
Comment

Background: GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. Results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2 (1). Identification of a functional homomeric GABABR2 coupled to adenylyl cyclase suggests that the complexity of GABAB pharmacological data is at least in part due to the presence of more than one receptor and opens avenues for future research leading to an understanding of metabotropic GABA receptor signal transduction mechanisms (2). The activity of GABA(B) R2 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment GABA(B) R2 Antibody Phospho (pS893) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications White, Wise, Main et al.: "Heterodimerization is required for the formation of a functional GABA(B) receptor." in: Nature, Vol. 396, Issue 6712, pp. 679-82, 1999 (PubMed).

Alternatives for antigen "gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2)", type "Antibodies"
Hosts (101), (9), (1), (1)
Reactivities (89), (78), (67), (42), (41), (30), (24), (12), (3), (2), (1), (1), (1), (1)
Applications (73), (40), (24), (23), (18), (15), (11), (4), (4), (3), (2), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (22), (19), (14), (8), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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