Prolactin-Induced Protein (PIP) antibody

Details for Product No. ABIN649781
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Antigen
Synonyms GCDFP-15, GP17, mSMGP, GCDFP15, GPIP4
Reactivity
Human
(67), (16), (14), (12), (1)
Host
Rabbit
(67), (20), (9)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(47), (43), (30), (26), (17), (13), (9), (6), (4), (1)
Pubmed 3 references available
Quantity 100 µL
Options
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Catalog No. ABIN649781
450.00 $
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Specificity A synthetic peptide corresponding to residues in human GCDFP-15 was used as an immunogen.
Alternative Name GCDFP-15
Background Gross cystic disease fluid protein (GCDFP-15), also called prolactin-inducible protein (PIP), is a single polypeptide chain with a versatile function in human reproductive and immunological systems (1). It is unique because of its small size (1). GCDFP-15 binds to CD4, exerts a potent inhibition on T lymphocyte apoptosis mediated by CD4/T-cell receptor (TCR) activation, and carries a fibronectin-specific aspartyl protease activity (2). Its ability to bind with other molecules like immunoglobulin G (IgG), actin, and zinc alpha2-glycoprotein (ZAG) shows its various biological activities (1). GCDFP-15 is expressed in benign and malignant human breast tumors and in normal exocrine organs such as sweat, salivary and lacrimal glands (1). It is up regulated by prolactin and androgens, while it is down regulated by estrogen (1). Due to its expression in breast cancer, GCDFP-15 is used as a prognostic biomarker (3, 4).
Molecular Weight 17 kDA
Gene ID 4436
UniProt P12273
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1 : 100-250, WB: = 1:5000
Comment

Background: Gross cystic disease fluid protein (GCDFP-15), also called prolactin-inducible protein (PIP), is a single polypeptide chain with a versatile function in human reproductive and immunological systems (1). It is unique because of its small size (1). GCDFP-15 binds to CD4, exerts a potent inhibition on T lymphocyte apoptosis mediated by CD4/T-cell receptor (TCR) activation, and carries a fibronectin-specific aspartyl protease activity (2). Its ability to bind with other molecules like immunoglobulin G (IgG), actin, and zinc alpha2-glycoprotein (ZAG) shows its various biological activities (1). GCDFP-15 is expressed in benign and malignant human breast tumors and in normal exocrine organs such as sweat, salivary and lacrimal glands (1). It is up regulated by prolactin and androgens, while it is down regulated by estrogen (1). Due to its expression in breast cancer, GCDFP-15 is used as a prognostic biomarker (3, 4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment GCDFP-15 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Hassan, Waheed, Yadav et al.: "Prolactin inducible protein in cancer, fertility and immunoregulation: structure, function and its clinical implications." in: Cellular and molecular life sciences : CMLS, Vol. 66, Issue 3, pp. 447-59, 2009 (PubMed).

Yan, Gidley, Horton et al.: "Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens." in: Diagnostic cytopathology, Vol. 37, Issue 7, pp. 475-8, 2009 (PubMed).

Debily, Marhomy, Boulanger et al.: "A functional and regulatory network associated with PIP expression in human breast cancer." in: PLoS ONE, Vol. 4, Issue 3, pp. e4696, 2009 (PubMed).

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