Heme Oxygenase (Decycling) 1 (HMOX1) antibody

Details for Product No. ABIN649819
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Antigen
Synonyms
HMOX1, HO1, MGC132176, wu:fc27c04, zgc:65984, ARABIDOPSIS THALIANA HEME OXYGENASE 1, ATHO1, F18A8.4, F18A8_4, GENOMES UNCOUPLED 2, GUN2, HEME OXYGENASE, HEME OXYGENASE 1, HEME OXYGENASE 6, HY1, HY6, P ... show more
HMOX1, HO1, MGC132176, wu:fc27c04, zgc:65984, ARABIDOPSIS THALIANA HEME OXYGENASE 1, ATHO1, F18A8.4, F18A8_4, GENOMES UNCOUPLED 2, GUN2, HEME OXYGENASE, HEME OXYGENASE 1, HEME OXYGENASE 6, HY1, HY6, PLASTID HEME OXYGENASE, REVERSAL OF THE DET PHENOTYPE 4, HMOX1D, HO-1, HSP32, bK286B10, D8Wsu38e, Hemox, Hmox, Hsp32, HEOXG, Heox, Ho-1, Ho1, hsp32, Hmox1 show less
Reactivity
Human
(130), (58), (42), (22), (22), (19), (14), (12), (5), (5), (5), (4), (2), (2)
Host
Rabbit
(116), (50), (1), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(13), (11), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(153), (73), (67), (40), (39), (35), (18), (15), (10), (9), (4), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN649819
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human HO-1 was used as an immunogen.
Alternative Name Heme Oxygenase-1 (HO-1)
Background Stressed mammalian cells up-regulate heme oxygenase 1 (HO-1), which catabolizes heme to biliverdin, carbon monoxide, and free iron. Results provide genetic evidence that up-regulation of HO-1 serves as an adaptive mechanism to protect cells from oxidative damage during stress (1). When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. HO-1 plays a crucial role in the inflammatory process during wound healing (2). TNFalpha accelerates inflammatory responses by down-regulating HO-1 expression in human monocytes. TNF antagonists may block this TNF-dependent suppression of HO-1 expression, resulting in an amelioration of inflammation (3).
Synonyms: HMOX1, HO, HO1, Heme oxygenase 1
Molecular Weight 32 kDA
Gene ID 3162
UniProt P09601
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:5000-10000 , IHC: = 1:100-250
Comment

Background: Stressed mammalian cells up-regulate heme oxygenase 1 (HO-1), which catabolizes heme to biliverdin, carbon monoxide, and free iron. Results provide genetic evidence that up-regulation of HO-1 serves as an adaptive mechanism to protect cells from oxidative damage during stress (1). When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. HO-1 plays a crucial role in the inflammatory process during wound healing (2). TNFalpha accelerates inflammatory responses by down-regulating HO-1 expression in human monocytes. TNF antagonists may block this TNF-dependent suppression of HO-1 expression, resulting in an amelioration of inflammation (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Heme Oxygenase-1 (HO-1) Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Poss, Tonegawa: "Reduced stress defense in heme oxygenase 1-deficient cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 20, pp. 10925-30, 1997 (PubMed).

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