V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) (C-Term) antibody

Details for Product No. ABIN649827
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms C76256, Erbb-3, Erbb3r, Her3, nuc-ErbB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, ERBB3
Epitope
C-Term
(27), (23), (19), (19), (18), (12), (10), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(298), (152), (132), (70), (44), (39), (24), (17), (1)
Host
Rabbit
(211), (105), (11), (1), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(14), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(182), (126), (84), (70), (66), (60), (49), (41), (20), (4), (4), (3), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN649827
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to C-terminal residues of human c-erbB3 was used as immunogen.
Alternative Name HER3 (ErbB3)
Background HER3 / ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. While ErbB3 is highly expressed in many cancer cells (4), ErbB3 may work together with other Erb members in tumorogenesis and proliferation (5).
Synonyms: ERBB3, HER3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3
Molecular Weight 185 kDA
Gene ID 2065
UniProt P21860
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes The suggested dilution is: WB: = 1:500
Comment

Background: HER3 / ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. While ErbB3 is highly expressed in many cancer cells (4), ErbB3 may work together with other Erb members in tumorogenesis and proliferation (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment HER3 (ErbB3) Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kraus, Issing, Miki et al.: "Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 23, pp. 9193-7, 1990 (PubMed).

Alimandi, Romano, Curia et al.: "Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas." in: Oncogene, Vol. 10, Issue 9, pp. 1813-21, 1995 (PubMed).

Katoh, Yazaki, Sugimura et al.: "c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase." in: Biochemical and biophysical research communications, Vol. 192, Issue 3, pp. 1189-97, 1993 (PubMed).

Guy, Platko, Cantley et al.: "Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 17, pp. 8132-6, 1994 (PubMed).

Sithanandam, Smith, Masuda et al.: "Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway." in: Carcinogenesis, Vol. 24, Issue 10, pp. 1581-92, 2003 (PubMed).

Hosts (211), (105), (11), (1), (1)
Reactivities (298), (152), (132), (70), (44), (39), (24), (17), (1)
Applications (182), (126), (84), (70), (66), (60), (49), (41), (20), (4), (4), (3), (2), (2), (1)
Conjugates (14), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (1), (1), (1), (1), (1)
Epitopes (27), (23), (19), (19), (18), (12), (10), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
back to top