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V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) (pTyr1289) antibody

Details for Product No. ABIN649828
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Antigen
Synonyms ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, nuc-ErbB3, C76256, Erbb-3, Erbb3r, Her3
Epitope
pTyr1289
(28), (24), (21), (19), (19), (16), (13), (12), (12), (5), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(319), (159), (136), (70), (44), (39), (24), (17), (1)
Host
Rabbit
(229), (104), (11), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(15), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (2), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(197), (120), (82), (74), (71), (70), (51), (36), (16), (6), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 µL
Options
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Catalog No. ABIN649828
507.14 $
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Specificity A phospho-specific peptide corresponding to residues surrounding Tyrosine 1289 of human HER3/ErbB3 was used as an immunogen. The antibody only detects HER3/ErbB3 phosphorylated on Tyrosine 1289.
Alternative Name HER3/ErbB3
Background HER3/ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of HER3/ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. HER3/ErbB3 is highly expressed in many cancer cells (4), and it may work together with other Erb members in tumorigenesis and proliferation (5). HER/ErbB3 is phosphorylated by EGFR or ErbB2 through dimeric interactions with HER/ErbB3, on Tyrosine 1289, a docking site for phosphatidylinositol 3-kinase (6).
Synonyms: ERBB3, HER3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3
Molecular Weight 185 kDA
Gene ID 2065
UniProt P21860
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Signaling, Chromatin
Application Notes The suggested dilution is: WB: = 1:5000
Comment

Background: HER3/ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of HER3/ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. HER3/ErbB3 is highly expressed in many cancer cells (4), and it may work together with other Erb members in tumorigenesis and proliferation (5). HER/ErbB3 is phosphorylated by EGFR or ErbB2 through dimeric interactions with HER/ErbB3, on Tyrosine 1289, a docking site for phosphatidylinositol 3-kinase (6).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment HER3/ErbB3 Antibody Phospho (pY1289) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Guy, Platko, Cantley et al.: "Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 17, pp. 8132-6, 1994 (PubMed).

Validation Images
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