V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) antibody

Details for Product No. ABIN649829
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Antigen
Synonyms erbb4, si:ch211-227n20.1, Her4, c-erbB-4, HER4, p180erbB4
Reactivity
Human, Rat (Rattus)
(251), (129), (126), (37), (37), (25), (25), (12), (1), (1), (1), (1), (1)
Host
Rabbit
(225), (29)
Clonality
Monoclonal
Conjugate
Un-conjugated
(19), (13), (13), (8), (8), (8), (8), (8), (8), (8), (8), (6), (6), (5)
Application
Western Blotting (WB)
(114), (80), (63), (61), (58), (23), (21), (19), (11), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN649829
392.86 $
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Specificity A synthetic peptide near the C-terminus (cytoplasmic domain) of human Her4/ErbB4 was used as immunogen.
Alternative Name HER4 (ErbB4)
Background HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
Synonyms: ERBB4, HER4, Receptor tyrosine-protein kinase erbB-4, p180erbB4,Tyrosine kinase-type cell surface receptor HER4
Molecular Weight 185 kDA
Gene ID 2066
UniProt Q15303
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes The suggested dilution is: WB: = 1:1000-2000
Comment

Background: HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment HER4 (ErbB4) Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Elenius, Corfas, Paul et al.: "A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester." in: The Journal of biological chemistry, Vol. 272, Issue 42, pp. 26761-8, 1997 (PubMed).

Garcia, Vasudevan, Buonanno: "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3596-601, 2000 (PubMed).

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