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Details for Product No. ABIN649831

V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (pTyr1162) antibody

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Antigen
Synonyms HER4, p180erbB4, Her4, c-erbB-4, erbb4, si:ch211-227n20.1
Epitope
»Alternatives pTyr1162
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN649831
Quantity 100 µL
Price
507.14 $   Plus shipping costs $45.00
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Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 1162 of human Her4/ErbB-4 was used as an immunogen. This antibody detects Her4/ErbB-4 phosphorylated on tyrosine 1162.
Alternative Name HER4 (ErbB4)
Background HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
Synonyms: ERBB4, HER4, Receptor tyrosine-protein kinase erbB-4, p180erbB4,Tyrosine kinase-type cell surface receptor HER4
Molecular Weight 180 kDA
Gene ID 2066
UniProt Q15303
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes The suggested dilution is: WB: ~~ 1:25000~50000 IP: ~~ 1:30 IHC: ~~ 1:100
Comment

Background: HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment HER4 (ErbB4) Antibody Phospho (pY1162) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Elenius, Corfas, Paul et al.: "A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester." in: The Journal of biological chemistry, Vol. 272, Issue 42, pp. 26761-8, 1997 (PubMed).

Garcia, Vasudevan, Buonanno: "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3596-601, 2000 (PubMed).

Alternatives for antigen "V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4)", type "Antibodies"
Hosts (192), (33)
Reactivities (220), (126), (124), (37), (37), (25), (25), (12), (2), (1), (1), (1), (1)
Applications (81), (80), (66), (48), (29), (25), (22), (18), (9), (2), (2), (2), (1)
Conjugates (14), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (1), (1)
Epitopes (20), (20), (19), (19), (14), (13), (12), (10), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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