V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (pTyr1258) antibody

Details for Product No. ABIN649833
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms HER4, p180erbB4, Her4, c-erbB-4, erbb4, si:ch211-227n20.1
Epitope
pTyr1258
(24), (19), (19), (17), (13), (12), (12), (10), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(216), (125), (124), (37), (37), (25), (25), (12), (1), (1), (1), (1), (1)
Host
Rabbit
(192), (28)
Clonality
Monoclonal
Conjugate
Un-conjugated
(14), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (1), (1)
Application
Western Blotting (WB)
(80), (79), (64), (48), (35), (21), (20), (16), (10), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN649833
Quantity 100 µL
Price
507.14 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 1258 of human Her4/ErbB-4 was used as an immunogen. This antibody detects Her4/ErbB-4 phosphorylated on tyrosine 1258.
Alternative Name Her4 (ErbB-4)
Background HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
Synonyms: ERBB4, HER4, Receptor tyrosine-protein kinase erbB-4, p180erbB4,Tyrosine kinase-type cell surface receptor HER4
Molecular Weight 180 kDA
Gene ID 2066
UniProt Q15303
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Chromatin, Signaling
Application Notes The suggested dilution is: WB: = 1:1000-5000
Comment

Background: HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Her4 (ErbB-4) Antibody Phospho (pY1258) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Plowman, Culouscou, Whitney et al.: "Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 5, pp. 1746-50, 1993 (PubMed).

Elenius, Corfas, Paul et al.: "A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester." in: The Journal of biological chemistry, Vol. 272, Issue 42, pp. 26761-8, 1997 (PubMed).

Garcia, Vasudevan, Buonanno: "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3596-601, 2000 (PubMed).

Hosts (192), (28)
Reactivities (216), (125), (124), (37), (37), (25), (25), (12), (1), (1), (1), (1), (1)
Applications (80), (79), (64), (48), (35), (21), (20), (16), (10), (2), (1), (1)
Conjugates (14), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (1), (1)
Epitopes (24), (19), (19), (17), (13), (12), (12), (10), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
back to top