V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (pTyr1056) antibody

Details for Product No. ABIN649834
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Antigen
Synonyms erbb4, si:ch211-227n20.1, Her4, c-erbB-4, HER4, p180erbB4
Epitope
pTyr1056
(35), (27), (20), (20), (14), (13), (12), (10), (9), (9), (7), (6), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(259), (130), (127), (37), (37), (25), (25), (12), (1), (1), (1), (1), (1)
Host
Rabbit
(233), (29)
Clonality
Monoclonal
Conjugate
Un-conjugated
(19), (13), (13), (8), (8), (8), (8), (8), (8), (8), (8), (6), (6), (5)
Application
Western Blotting (WB)
(122), (80), (65), (61), (58), (28), (22), (20), (12), (11), (3), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN649834
507.14 $
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Specificity A phospho-specific peptide corresponding to residues surrounding Tyrosine 1056 in human HER4/ErbB4 was used as an immunogen.
Alternative Name Her4
Background HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
Molecular Weight 180 kDA
Gene ID 861
UniProt Q15303
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes The suggested dilution is: WB: = 1:1000-10000
Comment

Background: HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Her4 Antibody Phospho (pY1056) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Plowman, Culouscou, Whitney et al.: "Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 5, pp. 1746-50, 1993 (PubMed).

Garcia, Vasudevan, Buonanno: "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3596-601, 2000 (PubMed).

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