|+1 404 474 4654|
|+1 888 205 9894 (TF)|
HIAP-1 (BIR3) antibody
Human, Rat (Rattus)
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
|2 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: BIRC3, API2, IAP1, MIHC, RNF49, Baculoviral IAP repeat-containing protein 3, RING finger protein 49|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues, before the breakpoint for translocation to form BIRC3-MALT1, of Human BIP3 was used as immunogen. The antibody does not cross-react with other IAP family members.|
|Molecular Weight||72 kDA|
Background: cIAP-2, also known as HIAP-1, is a member of the inhibitor of apoptosis (IAP) family of proteins. These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus (1). cIAP-2 is localized to the cytoplasm. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). This complex is thought to play a role in inhibition of apoptosis (2,3). cIAP-2 inhibits cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade and apoptosis (4).
|Application Notes||The suggested dilution is: WB: ~~ 1:5000 IP: ~~ 1:50 ICC: ~~ 1:100 IHC: ~~ 1:50|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||HIAP-1 (BIR3) Antibody can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Apoptosis/Necrosis, Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Rothe, Pan, Henzel et al.: "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins." in: Cell, Vol. 83, Issue 7, pp. 1243-52, 1996 (PubMed).
Deveraux, Roy, Stennicke et al.: "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases." in: The EMBO journal, Vol. 17, Issue 8, pp. 2215-23, 1998 (PubMed).