Hepatic Leukemia Factor (HLF) antibody

Antigen: Hepatic Leukemia Factor (HLF)

Synonyms: HLF, E230015K02Rik, DKFZp469P0721, Hlf, MGC33822

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Application: Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN649870

Additional Information

Alternative name: HLF

Gene ID: 3131

UniProt: Q16534

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues near the C-term in human HLF was used as an immunogen.

Molecular Weight: 36 kDA

Comments:

Background: Hepatic leukemia factor (HLF) is a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors (2). It is a transcription factor related to the CES-2 protein, which controls apoptosis of the NSM serotoninergic neurons (1). HLF has been linked to malignancies of the lymphoid system, but is not normally expressed in these cells. HLF transcripts are detected in the liver, kidney, lung and adult nervous system. It plays a role in the function of differentiated neurons in the adult nervous system (1), and it forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription (2).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:500~1000

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: HLF Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Cancer, Transcription Factors, Signaling, Chromatin, Cell Structure

Restrictions: For Research Use only

Publications

Product: Hitzler, Soares, Drolet et al.: "Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice." in: Brain research, Vol. 820, Issue 1-2, pp. 1-11, 1999 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).