Hepatic Leukemia Factor (HLF) antibody

Details for Product No. ABIN649870
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Antigen
Synonyms HLF, DKFZp469P0721, Hlf, HLF1, zgc:153035, Hif2a, HIF-2alpha, HIF2A, HRF, MOP2, bHLHe73, E230015K02Rik
Reactivity
Human, Rat (Rattus)
(33), (4), (2)
Host
Rabbit
(25), (9)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(34), (18), (6), (3), (1)
Pubmed 2 references available
Quantity 100 μL
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Specificity A synthetic peptide corresponding to residues near the C-term in human HLF was used as an immunogen.
Alternative Name HLF (HLF Antibody Abstract)
Background Hepatic leukemia factor (HLF) is a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors (2). It is a transcription factor related to the CES-2 protein, which controls apoptosis of the NSM serotoninergic neurons (1). HLF has been linked to malignancies of the lymphoid system, but is not normally expressed in these cells. HLF transcripts are detected in the liver, kidney, lung and adult nervous system. It plays a role in the function of differentiated neurons in the adult nervous system (1), and it forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription (2).
Molecular Weight 36 kDA
Gene ID 3131
UniProt Q16534
Research Area Cancer, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500-1000
Comment

Background: Hepatic leukemia factor (HLF) is a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors (2). It is a transcription factor related to the CES-2 protein, which controls apoptosis of the NSM serotoninergic neurons (1). HLF has been linked to malignancies of the lymphoid system, but is not normally expressed in these cells. HLF transcripts are detected in the liver, kidney, lung and adult nervous system. It plays a role in the function of differentiated neurons in the adult nervous system (1), and it forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment HLF Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Hitzler, Soares, Drolet et al.: "Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice." in: Brain research, Vol. 820, Issue 1-2, pp. 1-11, 1999 (PubMed).

Validation Images
Catalog No. ABIN649870
481.43 $
Plus shipping costs $45.00
Quantity
Price
100 μL
481.43 $

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