HtrA Serine Peptidase 2 (HTRA2) antibody

Details for Product No. ABIN649901
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Antigen
Synonyms OMI, PARK13, PRSS25, Omi, mnd2, Prss25, AI481710, CG8464, DmHtrA2, Dmel\\CG8464, HtrA2/Omi, dOmi, domi, htrA2, omi, HTRA2
Reactivity
Human, Rat (Rattus)
(108), (35), (32), (13), (13), (1)
Host
Rabbit
(77), (30)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(81), (52), (30), (23), (10), (9), (3), (3), (2), (2), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN649901
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues on human HtrA2 was used as an immunogen.
Alternative Name HtrA2
Background HtrA2 (Omi) is a serine protease that plays a significant role in apoptosis. Localized to the intermembrane space of the mitochondria, HtrA2 exists as at least four isoforms (1). In response to cellular stress signals, HtrA2 is released into the cytosol. HtrA2 induces cell death either by direct binding to BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC-inhibition-independent caspase-independent and Serine protease activity-dependent mechanism (2,3).
Synonyms: HTRA2, OMI, PRSS25, Serine protease HTRA2, mitochondrial, Omi stress-regulated endoprotease,Serine proteinase OMI,Serine protease 25
Molecular Weight 38 kDA
Gene ID 27429
UniProt O43464
Research Area Apoptosis/Necrosis, Cell Signaling, Cell Structure, Neurology, Metabolism
Application Notes IHC: = 1:100-250, WB: = 1:20000
Comment

Background: HtrA2 (Omi) is a serine protease that plays a significant role in apoptosis. Localized to the intermembrane space of the mitochondria, HtrA2 exists as at least four isoforms (1). In response to cellular stress signals, HtrA2 is released into the cytosol. HtrA2 induces cell death either by direct binding to BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC-inhibition-independent caspase-independent and Serine protease activity-dependent mechanism (2,3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment HtrA2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Savopoulos, Carter, Turconi et al.: "Expression, purification, and functional analysis of the human serine protease HtrA2." in: Protein expression and purification, Vol. 19, Issue 2, pp. 227-34, 2000 (PubMed).

Gray, Ward, Karran et al.: "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response." in: European journal of biochemistry / FEBS, Vol. 267, Issue 18, pp. 5699-710, 2000 (PubMed).

Hosts (77), (30)
Reactivities (108), (35), (32), (13), (13), (1)
Applications (81), (52), (30), (23), (10), (9), (3), (3), (2), (2), (2), (2), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1)
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