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Details for Product No. ABIN649902

HtrA Serine Peptidase 2 (HTRA2) (N-Term) antibody

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Antigen
Synonyms OMI, PARK13, PRSS25, Omi, mnd2, Prss25, AI481710, CG8464, DmHtrA2, Dmel\\CG8464, HtrA2/Omi, dOmi, domi, htrA2, omi, HTRA2
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Pubmed 3 references available
Catalog no. ABIN649902
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to N-terminal residues of mature form of human HtrA2 was used as immunogen. The antibody does not cross-react with other peptidase S1C family members.
Alternative Name HtrA2
Background HtrA2 (Omi) is a serine protease that plays a significant role in programmed cell death, or apoptosis. Localized to the intermembrane space of the mitochondria, HtrA2 exists predominantly as two isoforms (1). In response to cellular stress signals, HtrA2 is released into the cytosol. One way that HtrA2 induces apoptosis is by binding to BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), and thereby inhibiting their caspase-inhibitory activity (2,3).
Synonyms: HTRA2, OMI, PRSS25, Serine protease HTRA2, mitochondrial, Omi stress-regulated endoprotease,Serine proteinase OMI,Serine protease 25
Molecular Weight 38 kDA
Gene ID 27429
UniProt O43464
Research Area Apoptosis/Necrosis, Cell Signaling, Cell Structure, Metabolism, Neurology
Application Notes The suggested dilution is: WB: ~~ 1:500~2000 IP: ~~ 1:40 IHC: ~~ 1:250
Comment

Background: HtrA2 (Omi) is a serine protease that plays a significant role in programmed cell death, or apoptosis. Localized to the intermembrane space of the mitochondria, HtrA2 exists predominantly as two isoforms (1). In response to cellular stress signals, HtrA2 is released into the cytosol. One way that HtrA2 induces apoptosis is by binding to BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), and thereby inhibiting their caspase-inhibitory activity (2,3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment HtrA2 Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Savopoulos, Carter, Turconi et al.: "Expression, purification, and functional analysis of the human serine protease HtrA2." in: Protein expression and purification, Vol. 19, Issue 2, pp. 227-34, 2000 (PubMed).

Gray, Ward, Karran et al.: "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response." in: European journal of biochemistry / FEBS, Vol. 267, Issue 18, pp. 5699-710, 2000 (PubMed).

Suzuki, Imai, Nakayama et al.: "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death." in: Molecular cell, Vol. 8, Issue 3, pp. 613-21, 2001 (PubMed).

Alternatives for antigen "HtrA Serine Peptidase 2 (HTRA2)", type "Antibodies"
Hosts (81), (33)
Reactivities (118), (37), (34), (13), (13), (1)
Applications (88), (57), (31), (27), (10), (10), (5), (4), (2), (2), (2), (2), (2), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (7), (6), (4), (4), (4), (3), (3), (2), (1), (1)
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