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Details for Product No. ABIN649913

Interleukin 1, beta (IL1B) antibody

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Antigen
Synonyms IL-1, IL1F2, IL1-BETA, IL-1BETA, IL1beta, IL-1B, IL-1beta, Il-1b, IL1B, il1-b, zgc:111873
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN649913
Quantity 100 µL
Price
392.86 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A recombinant human IL-1 beta protein was used as an immunogen.
Alternative Name IL-1 beta
Background Interleukin 1 beta (IL1 beta) is a pro-inflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursors. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. Recent studies have shown IL1 beta to be a major cause of severe inflammation in the mouse model of Crohns disease, implicating IL1 beta as a potential marker for this disease (4).
Synonyms: IL1B, IL1F2, Interleukin-1 beta, Catabolin
Molecular Weight 17 kDA
Gene ID 3553
UniProt P01584
Research Area Cell Signaling, Cell Cycle, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:20000
Comment

Background: Interleukin 1 beta (IL1 beta) is a pro-inflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursors. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. Recent studies have shown IL1 beta to be a major cause of severe inflammation in the mouse model of Crohns disease, implicating IL1 beta as a potential marker for this disease (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment IL-1 beta Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).

Yuan, Shaham, Ledoux et al.: "The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme." in: Cell, Vol. 75, Issue 4, pp. 641-52, 1993 (PubMed).

Dinarello: "Biologic basis for interleukin-1 in disease." in: Blood, Vol. 87, Issue 6, pp. 2095-147, 1996 (PubMed).

Alternatives for antigen "Interleukin 1, beta (IL1B)", type "Antibodies"
Hosts (203), (153), (12), (10), (5), (5), (4), (3), (1)
Reactivities (256), (101), (74), (29), (18), (18), (9), (8), (5), (4), (4), (3), (3), (1), (1), (1)
Applications (255), (221), (78), (51), (42), (33), (29), (22), (21), (19), (18), (14), (14), (8), (7), (7), (7), (5), (4), (4), (4), (3), (2), (2), (2), (1), (1)
Conjugates (56), (20), (10), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (14), (9), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1)
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