|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Interleukin 1, beta (IL1B) (C-Term) antibody
|Synonyms||IL-1, IL1F2, IL1-BETA, IL1B, IL-1BETA, MGC111873, zgc:111873, IL-1B|
Alternatives Western Blotting (WB)
|2 references available|
|Price||392.86 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||IL-1 beta|
|Description||Other names: IL1B, IL1F2, Interleukin-1 beta, Catabolin|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues in the C-terminus of human IL1-beta was used as immunogen|
|Molecular Weight||17 kDA|
Background: Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn's disease which makes IL1 beta an important target for this disease (4).
|Application Notes||The suggested dilution is: WB: ~~ 1:5000|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||IL-1 beta Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Cell Signaling, Cell Cycle, Cell Structure|
|Restrictions||For Research Use only|
March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).
Yuan, Shaham, Ledoux et al.: "The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme." in: Cell, Vol. 75, Issue 4, pp. 641-52, 1993 (PubMed).