Interleukin 1, beta (IL1B) (C-Term) antibody

Details for Product No. ABIN649914
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms il1-b, zgc:111873, IL-1beta, Il-1b, IL1B, IL-1, IL1-BETA, IL1F2, IL-1BETA, IL1beta, IL-1B
Epitope
C-Term
(19), (17), (9), (8), (6), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(273), (125), (75), (29), (19), (17), (17), (10), (5), (5), (4), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(252), (144), (12), (11), (10), (7), (5), (4), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(57), (22), (12), (11), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(284), (259), (89), (60), (43), (34), (34), (33), (32), (20), (19), (14), (13), (8), (6), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649914
392.86 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in the C-terminus of human IL1-beta was used as immunogen
Alternative Name IL-1 beta
Background Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn's disease which makes IL1 beta an important target for this disease (4).
Synonyms: IL1B, IL1F2, Interleukin-1 beta, Catabolin
Molecular Weight 17 kDA
Gene ID 3553
UniProt P01584
Research Area Cell Signaling, Cell Cycle, Cell Structure
Application Notes The suggested dilution is: WB: = 1:5000
Comment

Background: Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn's disease which makes IL1 beta an important target for this disease (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment IL-1 beta Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).

Yuan, Shaham, Ledoux et al.: "The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme." in: Cell, Vol. 75, Issue 4, pp. 641-52, 1993 (PubMed).

Validation Images
Did you look for something else?
back to top