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Interleukin 1, beta (IL1B) (C-Term) antibody

Antigen

Interleukin 1, beta (IL1B)
Synonyms IL-1, IL1F2, IL1-BETA, IL1B, IL-1BETA, MGC111873, zgc:111873, IL-1B
Binding Site
Alternatives

C-Term
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN649914
Quantity 100ul
Price 392.86 $   Plus shipping costs $45.00
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Additional Information
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Alternative name IL-1 beta
Gene ID 3553
UniProt P01584
Description Other names: IL1B, IL1F2, Interleukin-1 beta, Catabolin
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues in the C-terminus of human IL1-beta was used as immunogen
Molecular Weight 17 kDA
Comments

Background: Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn's disease which makes IL1 beta an important target for this disease (4).

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Application Notes The suggested dilution is: WB: ~~ 1:5000
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage IL-1 beta Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Research Area Cell Signaling, Cell Cycle, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).

Yuan, Shaham, Ledoux et al.: "The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme." in: Cell, Vol. 75, Issue 4, pp. 641-52, 1993 (PubMed).