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Interleukin 17A (IL17A) antibody

Antigen

Interleukin 17A (IL17A)
Synonyms IL17, CTLA8, IL-17, IL-17A, Il17, Ctla8, Ctla-8, IL17F, IL17A, ChIL-17
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN649918
Quantity 100ul
Price 392.86 $   Plus shipping costs $45.00
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Additional Information
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Alternative name IL-17
Gene ID 3605
UniProt Q16552
Description Other names: IL17A, CTLA8, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8
Characteristics Rabbit Monoclonal Antibody
Specificity A recombinant human IL-17 was used an immunogen.
Molecular Weight 32 kDA
Comments

Background: Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by TCRα,/β,+ CD4 CD8 thymocytes, as well as by activated CD4+ and CD4+ CD45RO+ memory T cells (1). IL-17 stimulates the expression of TNFalpha, IL-1 beta, IL-6, and IL-8 (2). In addition, IL-17 is involved in the induction of inducible nitric oxide synthase and cyclooxygenase 2 in chondrocytes (3). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis (4).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:1000~5000
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage IL-17 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Cell Signaling, Protein Modifications, Cell Structure
Restrictions For Research Use only

Publications
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Product Yao, Painter, Fanslow et al.: "Human IL-17: a novel cytokine derived from T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 12, pp. 5483-6, 1996 (PubMed).

Fossiez, Banchereau, Murray et al.: "Interleukin-17." in: International reviews of immunology, Vol. 16, Issue 5-6, pp. 541-51, 1998 (PubMed).

Ziolkowska, Koc, Luszczykiewicz et al.: "High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 5, pp. 2832-8, 2000 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Interleukin 17A (IL17A)", type "Antibodies"
Hosts Rabbit (94), Mouse (86), Rat (26), Goat (17), Guinea Pig (3), Chicken (1)
Reactivities Human (166), Mouse (Murine) (64), Rat (Rattus) (29), Rabbit (3), Cow (Bovine) (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1), Pig (Porcine) (1)
Applications ELISA (113), Western Blotting (WB) (103), Flow Cytometry (FACS) (86), Immunofluorescence (IF) (34), Neutralization (Neut) (26), Immunohistochemistry (IHC) (18), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), ELISA (Detection) (14), ELISA (Capture) (10), ELISPOT (8), Functional Studies (Func) (8), Fluorescence Microscopy (FM) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunoprecipitation (IP) (5), Blocking Antibody (Inhibition) (3), ELISpot (2), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Blocking Antibody (Inhibition) (1), Dot Blot (DB) (1), Immunocytochemistry (ICC) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (40), HRP (14), PE (12), Alexa Fluor 647 (5), FITC (5), Alexa Fluor (4), Alexa Fluor 488 (4), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), APC (1)
Epitopes AA 1-75 (5), N-Term (4), Internal Region (3), AA 20-155 (2), AA 126-137 (1), AA 25-155 (1), Center (1), Internal Region,AA 126-137 (1), Middle Region (1)