Did you know that you can buy products from over 140 different suppliers from us?

Interleukin 18 Binding Protein (IL18BP) antibody

Details for Product No. ABIN649919
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms IL18BP, IL-18BP, Igifbp, MC54L, IL18BPa
Reactivity
Human, Rat (Rattus)
(44), (28), (14), (12), (12)
Host
Rabbit
(46), (9), (6)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(49), (39), (10), (9), (5), (5), (3), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649919
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues near the N-terminus of human IL18BP was used as an immunogen.
Alternative Name IL-18BP
Background IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).
Synonyms: IL18BP, Interleukin-18-binding protein, Tadekinig-alfa
Molecular Weight 40 kDA
Gene ID 10068
UniProt O95998
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:50-100, WB: = 1:500
Comment

Background: IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment IL-18BP Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Nakanishi, Yoshimoto, Tsutsui et al.: "Interleukin-18 regulates both Th1 and Th2 responses." in: Annual review of immunology, Vol. 19, pp. 423-74, 2001 (PubMed).

Nicklin, Barton, Nguyen et al.: "A sequence-based map of the nine genes of the human interleukin-1 cluster." in: Genomics, Vol. 79, Issue 5, pp. 718-25, 2002 (PubMed).

Validation Images
back to top