Interleukin 2 (IL2) antibody

Details for Product No. ABIN649921
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Antigen
Synonyms IL-2, TCGF, lymphokine, Il-2, POIL2, IL2, il2
Reactivity
Human
(231), (150), (76), (13), (11), (10), (8), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(173), (172), (101), (10), (3), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(55), (24), (12), (9), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(289), (222), (78), (53), (50), (40), (35), (33), (25), (23), (21), (16), (12), (9), (9), (7), (4), (4), (4), (3), (2), (2), (2), (2), (2)
Pubmed 4 references available
Catalog no. ABIN649921
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
Options
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Specificity A synthetic peptide corresponding to residues in human IL-2 was used as an immunogen.
Alternative Name IL-2
Background Interleukin-2 (IL-2) is an immunoregulatory cytokine that functions as a growth factor and central regulator in the immune system (1, 2). It participates in modulating the immune response by helping control the rate of clonal expansion of lymphocytes (3). IL-2 acts through a quaternary receptor signaling complex containing alpha, beta, and common gamma chain receptors (1). IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial for regulation of the immune response. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (4).
Synonyms: TNFAIP3, Tumor necrosis factor, alpha-induced protein 3, Putative DNA-binding protein A20,Zinc finger protein A20
Molecular Weight 18 kDA
Gene ID 3558
UniProt P60568
Research Area Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Signaling, Chromatin, Cell Structure
Application Notes IHC: = 1:250-500, WB: = 1:1000-5000
Comment

Background: Interleukin-2 (IL-2) is an immunoregulatory cytokine that functions as a growth factor and central regulator in the immune system (1, 2). It participates in modulating the immune response by helping control the rate of clonal expansion of lymphocytes (3). IL-2 acts through a quaternary receptor signaling complex containing alpha, beta, and common gamma chain receptors (1). IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial for regulation of the immune response. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment IL-2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Bamborough, Hedgecock, Richards: "The interleukin-2 and interleukin-4 receptors studied by molecular modelling." in: Structure (London, England : 1993), Vol. 2, Issue 9, pp. 839-51, 1995 (PubMed).

Wang, Rickert, Garcia: "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1159-63, 2005 (PubMed).

Stauber, Debler, Horton et al.: "Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 8, pp. 2788-93, 2006 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Hosts (173), (172), (101), (10), (3), (2), (1)
Reactivities (231), (150), (76), (13), (11), (10), (8), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applications (289), (222), (78), (53), (50), (40), (35), (33), (25), (23), (21), (16), (12), (9), (9), (7), (4), (4), (4), (3), (2), (2), (2), (2), (2)
Conjugates (55), (24), (12), (9), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2)
Epitopes (6), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1)
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