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IL-6 antibody

Antigen

IL-6
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
1 reference available
Certificates ISO 9001:2008
Catalog no. ABIN649924
Quantity 100ul
Price 392.86 $   Plus shipping costs $45.00
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Additional Information
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Gene ID 3569
UniProt P05231
Description Other names: IL6, IFNB2, Interleukin-6, Interferon beta-2,Hybridoma growth factor,CTL differentiation factor
Characteristics Rabbit Monoclonal Antibody
Specificity A recombinant human IL-6 protein was used as immunogen.
Molecular Weight 22 kDA
Comments

Background: Interleukin-6 (IL-6) is a multifunctional cytokine with a wide variety of biological functions. IL-6 is implicated in the final differentiation of B-cells into immunoglobulin-secreting cells (1), myeloma and plasmacytoma growth (2), nerve cell differentiation, and activation of hepatocytes and mitogen-stimulated helper T cells (3). Upon activation, IL-6 induces at least three major signaling pathways: JAK/STAT, PI-3 kinase and MAPK (4,5).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:10000
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage IL-6 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Hirano, Yasukawa, Harada et al.: "Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin." in: Nature, Vol. 324, Issue 6092, pp. 73-6, 1986 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "IL-6", type "Antibodies"
Hosts Rabbit (243), Mouse (111), Rat (78), Goat (20), Sheep (4), Guinea Pig (3)
Reactivities Human (246), Mouse (Murine) (131), Rat (Rattus) (84), Sheep (Ovine) (42), Cow (Bovine) (37), Horse (Equine) (37), Pig (Porcine) (37), Dog (Canine) (34), Rabbit (20), 8 hydroxy 2’ deoxyguanosine (3), Chicken (3), Goat (3), Rhesus Monkey (3), Wild boar (Sus scrofa) (3), Monkey (2), Baboon (1)
Applications ELISA (278), Western Blotting (WB) (236), Immunofluorescence (IF) (134), Immunohistochemistry (IHC) (50), Immunoprecipitation (IP) (49), Neutralization (Neut) (44), Functional Studies (Func) (41), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (39), Flow Cytometry (FACS) (36), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (21), Immunoassay (IA) (13), Immunocytochemistry (ICC) (13), Dot Blot (Dot) (12), Cellular Assay (CA) (10), Immunostaining (ISt) (10), Blocking Antibody (Inhibition) (8), Immunoelectron Microscopy (IEM) (8), Blocking Antibody (Inhibition) (7), Immunohistochemistry (Fixed) (IHC (fx)) (6), ELISPOT (4), Fluorescence Microscopy (FM) (4), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Radioimmunoassay (RIA) (3), Immunohistochemistry (Paraffin-embedded Sections) pro (IHC (p)+) (2), Intracellular Staining (IS) (2), ELISA (Capture) (1), ELISA (Detection) (1), ELISpot (1), Electrophoretic Mobility-Shift Assay (EMSA) (1), Transfected cell culture (TCC) (1)
Conjugates Biotin (57), FITC (17), PE (13), HRP (11), Alexa Fluor 350 (8), Alexa Fluor 555 (8), Alexa Fluor 647 (8), Cy3 (8), Cy5 (8), Cy5.5 (8), Cy7 (8), Gold (8), PE,Cy3 (8), PE,Cy5 (8), PE,Cy5.5 (8), PE,Cy7 (8), Alexa Fluor 488 (7), RPE (1)
Epitopes Internal Region (2), AA 21-211 (1), C-Term,AA 195-211 (1), Center (1)