Integrin-Linked Kinase (ILK) antibody

Details for Product No. ABIN649928
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Antigen
Synonyms CG10504, CT29478, DmILK, Dmel\\CG10504, ILK, ilk, l(3)78Ca, p59, AA511515, ESTM24, zgc:65842, ILK-1, ILK-2, P59, p59ILK
Reactivity
Human, Rat (Rattus)
(120), (70), (67), (49), (49), (49), (36), (3), (2), (2)
Host
Rabbit
(121), (5), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(69), (47), (40), (34), (25), (8), (4), (2), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN649928
450.00 $
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Specificity A synthetic peptide corresponding to residues near N-term of human ILK protein was used as immunogen
Alternative Name ILK
Background Integrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3).
Synonyms: ILK, ILK1, ILK2, Integrin-linked protein kinase, ILK-1,ILK-2,59 kDa serine/threonine-protein kinase,p59ILK
Molecular Weight 51 kDA
Gene ID 3611
UniProt Q13418
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes IHC: = 1:50-100, WB: = 1:10000-200000
Comment

Background: Integrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment ILK Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Marotta, Tan, Gray et al.: "Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis." in: Oncogene, Vol. 20, Issue 43, pp. 6250-7, 2001 (PubMed).

Wu, Dedhar: "Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 505-10, 2001 (PubMed).

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