Indian Hedgehog (IHH) antibody

Details for Product No. ABIN649930
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Antigen
Synonyms BDA1, HHG2, X-hh, Xbhh, bhh, bhh-a, IHH, ehh, zgc:113262
Reactivity
Human, Rat (Rattus)
(45), (32), (23), (12), (12), (1), (1), (1)
Host
Rabbit
(41), (10), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(44), (25), (11), (10), (10), (7), (5), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN649930
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues near the N-terminus of human IHH was used as an immunogen.
Background Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer (1). The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (IHH) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone (2). It has been shown that IHH, synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development (3).
Synonyms: IHH, Indian hedgehog protein C-product, HHG-2
Molecular Weight 45 kDA
Gene ID 3549
UniProt Q14623
Research Area Cell Signaling, Protein Modifications, Cell Structure, Metabolism
Application Notes The suggested dilution is: WB: = 1:1000 , IHC: = 1:250-500
Comment

Background: Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer (1). The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (IHH) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone (2). It has been shown that IHH, synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Indian Hedgehog Antibody (IHH) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Chung, Schipani, McMahon et al.: "Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development." in: The Journal of clinical investigation, Vol. 107, Issue 3, pp. 295-304, 2001 (PubMed).

Hosts (41), (10), (2), (1)
Reactivities (45), (32), (23), (12), (12), (1), (1), (1)
Applications (44), (25), (11), (10), (10), (7), (5), (2), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (3), (3), (2), (2), (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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