Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa (INPP4A) antibody

Details for Product No. ABIN649932
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Antigen
Synonyms 107kDa, 9630012D15, D130048C09Rik, R74740, INPP4, TVAS1
Reactivity
Human, Rat (Rattus)
(7)
Host
Rabbit
(7)
Clonality
Monoclonal
Application
Western Blotting (WB)
(7), (3), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN649932
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human INPP4A was used as an immunogen.
Alternative Name INPP4A
Background Inositol polyphosphate 4-phosphatase (INPP4A), an enzyme of the inositol phosphate signaling pathway, catalyzes the hydrolysis of the 4-position phosphate of inositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and phosphatidylinositol 3,4-bisphosphate (1). Hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate has been implicated in mitogenesis mediated by PDGF receptor, the oxidative burst of neutrophils, and translocation of the glucose transporter to the plasma membrane (2).
Synonyms: INPP4A, Type I inositol-3,4-bisphosphate 4-phosphatase, Inositol polyphosphate 4-phosphatase type I
Molecular Weight 104 kDA
Gene ID 3631
UniProt Q96PE3
Research Area Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-2000
Comment

Background: Inositol polyphosphate 4-phosphatase (INPP4A), an enzyme of the inositol phosphate signaling pathway, catalyzes the hydrolysis of the 4-position phosphate of inositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and phosphatidylinositol 3,4-bisphosphate (1). Hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate has been implicated in mitogenesis mediated by PDGF receptor, the oxidative burst of neutrophils, and translocation of the glucose transporter to the plasma membrane (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment INPP4A Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Norris, Auethavekiat, Majerus: "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase." in: The Journal of biological chemistry, Vol. 270, Issue 27, pp. 16128-33, 1995 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

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