Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa (INPP4A) antibody

Antigen: Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa (INPP4A)

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Application: Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN649932

Additional Information

Alternative name: INPP4A

Gene ID: 3631

UniProt: Q96PE3

Description: Other names: INPP4A, Type I inositol-3,4-bisphosphate 4-phosphatase, Inositol polyphosphate 4-phosphatase type I

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues near the C-terminus of human INPP4A was used as an immunogen.

Molecular Weight: 104 kDA

Comments:

Background: Inositol polyphosphate 4-phosphatase (INPP4A), an enzyme of the inositol phosphate signaling pathway, catalyzes the hydrolysis of the 4-position phosphate of inositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and phosphatidylinositol 3,4-bisphosphate (1). Hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate has been implicated in mitogenesis mediated by PDGF receptor, the oxidative burst of neutrophils, and translocation of the glucose transporter to the plasma membrane (2).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~2000

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: INPP4A Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Publications

Product: Norris, Auethavekiat, Majerus: "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase." in: The Journal of biological chemistry, Vol. 270, Issue 27, pp. 16128-33, 1995 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).