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Integrin beta 3 (ITGB3) antibody

Antigen

Integrin beta 3 (ITGB3)
Synonyms LAD, CD18, MF17, MFI7, LCAMB, LFA-1, MAC-1, CD61, GP3A, GPIIIa, INGRB3, MGC159221, MGC159223, integrin, ITGB3
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunoprecipitation (IP)
4 references available
Certificates ISO 9001:2008
Catalog no. ABIN649937
Quantity 100ul
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name Integrin beta-3 (CD61)
Gene ID 3690
UniProt P05106
Description Other names: ITGB3, GP3A, Integrin beta-3, Platelet membrane glycoprotein IIIa
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues in human Integrin beta-3 (CD61 antigen) was used as an immunogen.
Molecular Weight 110 kDA
Comments

Background: Integrin beta-3 (CD61 antigen, GP IIIa) is a member of the integrin family of integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins (1). Integrin beta-3 forms a Ca2+-dependent heterodimer complex with the GP IIb chain in platelets (2). The cytoplasmic domain of Integrin beta-3 has be suggested to have a key role in cell adhesion (3). Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces (4).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:1000 IP: ~~ 1:50
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Integrin beta-3 (CD61) Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Fitzgerald, Steiner, Rall et al.: "Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to "integrin"." in: The Journal of biological chemistry, Vol. 262, Issue 9, pp. 3936-9, 1987 (PubMed).

Kumar, James, Wong et al.: "Cloning and characterization of a novel integrin beta3 subunit." in: The Journal of biological chemistry, Vol. 272, Issue 26, pp. 16390-7, 1997 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Integrin beta 3 (ITGB3)", type "Antibodies"
Hosts Mouse (128), Rabbit (125), Hamster (34), Rat (1)
Reactivities Human (236), Mouse (Murine) (125), Rat (Rattus) (67), Pig (Porcine) (22), Cow (Bovine) (20), Monkey (9), Primate (6), Dog (Canine) (2), Cat (Feline) (1), Chicken (1), Hamster (1), Horse (Equine) (1), Sheep (Ovine) (1)
Applications Flow Cytometry (FACS) (144), Western Blotting (WB) (98), Immunofluorescence (IF) (55), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (53), ELISA (37), Immunohistochemistry (IHC) (37), Immunoprecipitation (IP) (33), Immunohistochemistry (Frozen Sections) (IHC (fro)) (20), Immunohistochemistry (Fixed) (IHC (fx)) (17), Immunocytochemistry (ICC) (9), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (9), Functional Studies (Func) (4), Immunoelectron Microscopy (IEM) (3), Enzyme Immunoassay (EIA) (1)
Conjugates FITC (43), PE (25), Biotin (17), RPE (7), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), Gold (3), HRP (3), PE,Cy3 (3), PE,Cy5 (3), PE,Cy5.5 (3), PE,Cy7 (3), APC (2)
Epitopes pTyr773 (31), pTyr785 (30), C-Term (22), N-Term (7), Tyr785 (4), Tyr773 (3), C-Term,AA 734-760 (1), C-Term,AA 740-769 (1), Internal Region (1)