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Details for Product No. ABIN649941

Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody

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Antigen
Synonyms ASRT5, IRAKM, IrakM, IRAK-M, AI563835, 4833428C18Rik, IRAK3, si:dkey-150i15.2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN649941
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in the C-term of human IRAK-3 was used as immunogen.
Alternative Name IRAK-3
Background IRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5).
Synonyms: IRAK3, Interleukin-1 receptor-associated kinase 3, IL-1 receptor-associated kinase M
Molecular Weight 68 kDA
Gene ID 11213
UniProt Q9Y616
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000 IP: ~~ 1:50
Comment

Background: IRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment IRAK-3 Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Kanakaraj, Ngo, Wu et al.: "Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice." in: The Journal of experimental medicine, Vol. 189, Issue 7, pp. 1129-38, 1999 (PubMed).

Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 3 (IRAK3)", type "Antibodies"
Hosts (53), (8), (8)
Reactivities (57), (26), (22), (1)
Applications (68), (35), (20), (15), (12), (6), (2), (1), (1)
Epitopes (28), (5), (5), (4), (3), (2), (2), (2), (1), (1), (1)
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