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Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (N-Term) antibody

Antigen

Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)
Synonyms IPD1, REN64, NY-REN-64, IRAK4, IRAK-4, 8430405M07Rik, 9330209D03Rik, MGC55553, zgc:55553, MGC137816, ren64, ny-ren-64, irak4
Binding Site
Alternatives

N-Term
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunocytochemistry (ICC)
1 reference available
Certificates ISO 9001:2008
Catalog no. ABIN649942
Quantity 100ul  (Variants)
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name IRAK-4
Gene ID 55127
UniProt Q9NW23
Description Other names: HEATR1, BAP28, HEAT repeat-containing protein 1, Protein BAP28
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues in the N-term of human IRAK-4 was used as immunogen.
Molecular Weight 52 kDA
Comments

Background: IRAK-4 is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon phosphorylation, IRAK-4 interacts with IRAK-1, MYD88 and TRAF6 to form a complex, and activate NF-kB and MAPK pathways (2-3). IRAK-4 phosphorylates and activates IRAK-1 at thr387 and is also known to interact with IRAK-1 but not with the other IRAK members. Additionally, like IRAK-1, IRAK-4 possesses an auto and cross-phosphorylation kinase activity (4).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:500~2000 ICC: ~~ 1:50~100
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage IRAK-4 Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Restrictions For Research Use only

Publications
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Product Li, Strelow, Fontana et al.: "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5567-72, 2002 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)", type "Antibodies"
Hosts Rabbit (55), Mouse (17), Goat (8)
Reactivities Human (76), Mouse (Murine) (33), Cow (Bovine) (23), Dog (Canine) (23), Pig (Porcine) (23), Rat (Rattus) (23), Sheep (Ovine) (23), Horse (Equine) (18), Monkey (3), Chimpanzee (1)
Applications Western Blotting (WB) (46), ELISA (27), Immunofluorescence (IF) (27), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (14), Immunocytochemistry (ICC) (8), Immunohistochemistry (IHC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Immunoprecipitation (IP) (2), Dot Blot (DB) (1), Flow Cytometry (FACS) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 488 (6), Alexa Fluor 546 (4), Biotin (3), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes C-Term (14), N-Term (9), pThr345 (4), AA 38-54 (1), AA 436-459 (1), pTyr216 (1)