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Tyrosine-Protein Kinase JAK3 (JAK3) antibody

Details for Product No. ABIN649957
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Antigen
Synonyms JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN, fae, wil, RATJAK3, JAK
Reactivity
Human
(72), (58), (46), (37), (37), (25), (1)
Host
Rabbit
(57), (18)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(37), (34), (30), (13), (10), (8), (7), (5), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649957
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues on the N-terminus in human JAK3 was used as an immunogen.
Alternative Name JAK3
Background JAK3 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors, upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5).
Molecular Weight 115 kDA
Gene ID 4436
UniProt P52333
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Signaling, Chromatin
Application Notes The suggested dilution is: WB: = 1:10000-20000
Comment

Background: JAK3 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors, upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment JAK3 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Malabarba, Kirken, Rui et al.: "Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha." in: The Journal of biological chemistry, Vol. 270, Issue 16, pp. 9630-7, 1995 (PubMed).

Leonard, OShea: "Jaks and STATs: biological implications." in: Annual review of immunology, Vol. 16, pp. 293-322, 1998 (PubMed).

Pesu, Candotti, Husa et al.: "Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs." in: Immunological reviews, Vol. 203, pp. 127-42, 2005 (PubMed).

Cornejo, Kharas, Werneck et al.: "Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models." in: Blood, Vol. 113, Issue 12, pp. 2746-54, 2009 (PubMed).

Vaysberg, Lambert, Krams et al.: "Activation of the JAK/STAT pathway in Epstein Barr virus+-associated posttransplant lymphoproliferative disease: role of interferon-gamma." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 9, Issue 10, pp. 2292-302, 2009 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649957
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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