F11 Receptor (F11R) (N-Term) antibody

Details for Product No. ABIN649959
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Antigen
Synonyms CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1, Jcam, JAM-1, JAM-A, Jcam1, Ly106, ESTM33, AA638916, 9130004G24, Jam1
Epitope
N-Term
(5), (5), (4), (1), (1)
Reactivity
Human, Rat (Rattus)
(54), (35), (21), (18), (18), (17)
Host
Rabbit
(33), (19), (12), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(40), (35), (16), (14), (12), (10), (9), (7), (6), (5), (4), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN649959
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues near the N-terminus of human JAM1 was used as an immunogen.
Alternative Name JAM1
Background Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. JAM is selectively concentrated at intercellular junctions of endothelial and epithelial cells of different origins. Microscopy shows that JAM codistributes with tight junction components at the apical region of the intercellular cleft. A mAb directed to JAM (BV11) was found to inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer in vitro. Systemic treatment of mice with BV11 mAb blocked monocyte infiltration upon chemokine administration in subcutaneous air pouches (1). The human protein shares a highly conserved structure and sequence with the murine protein. However it is distinct in that it is constitutively expressed on circulating neutrophils, monocytes, platelets and lymphocyte subsets (2).
Synonyms: F11R, JAM1, JCAM, Junctional adhesion molecule A, Platelet F11 receptor
Molecular Weight 33 kDA
Gene ID 50848
UniProt Q9Y624
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:2000
Comment

Background: Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. JAM is selectively concentrated at intercellular junctions of endothelial and epithelial cells of different origins. Microscopy shows that JAM codistributes with tight junction components at the apical region of the intercellular cleft. A mAb directed to JAM (BV11) was found to inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer in vitro. Systemic treatment of mice with BV11 mAb blocked monocyte infiltration upon chemokine administration in subcutaneous air pouches (1). The human protein shares a highly conserved structure and sequence with the murine protein. However it is distinct in that it is constitutively expressed on circulating neutrophils, monocytes, platelets and lymphocyte subsets (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment JAM1 Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Martìn-Padura, Lostaglio, Schneemann et al.: "Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration." in: The Journal of cell biology, Vol. 142, Issue 1, pp. 117-27, 1998 (PubMed).

Williams, Martin-Padura, Dejana et al.: "Identification and characterisation of human Junctional Adhesion Molecule (JAM)." in: Molecular immunology, Vol. 36, Issue 17, pp. 1175-88, 2000 (PubMed).

Hosts (33), (19), (12), (2)
Reactivities (54), (35), (21), (18), (18), (17)
Applications (40), (35), (16), (14), (12), (10), (9), (7), (6), (5), (4), (2), (2), (1)
Conjugates (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (5), (4), (1), (1)
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