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Lamin B Receptor Receptor antibody

Details for Product No. ABIN649975
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Antigen
Reactivity
Human, Rat (Rattus)
Host
Rabbit
Clonality
Monoclonal
Application
Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN649975
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Specificity A synthetic peptide corresponding to residues of human Lamin B Receptor was used as immunogen.
Background Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).
Synonyms: LBR, Lamin-B receptor, Integral nuclear envelope inner membrane protein,LMN2R
Molecular Weight 71 kDA
Gene ID 3930
UniProt Q14739
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Transcription Factors
Application Notes The suggested dilution is: WB: = 1:5000
Comment

Background: Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Lamin B Receptor Antibody Receptor can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Oberhammer, Hochegger, Fröschl et al.: "Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase." in: The Journal of cell biology, Vol. 126, Issue 4, pp. 827-37, 1994 (PubMed).

Ye, Worman: "Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane." in: The Journal of biological chemistry, Vol. 269, Issue 15, pp. 11306-11, 1994 (PubMed).

Rao, Perez, White: "Lamin proteolysis facilitates nuclear events during apoptosis." in: The Journal of cell biology, Vol. 135, Issue 6 Pt 1, pp. 1441-55, 1997 (PubMed).

Validation Images
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