Did you know that you can buy products from over 140 different suppliers from us?

Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1) (N-Term) antibody

Details for Product No. ABIN650005
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms MLT, MLT1, A630046N12, D430033E09Rik, malt1, MALT1, mlt, mlt1
Epitope
N-Term
(10), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(65), (25), (19), (11)
Host
Rabbit
(56), (9), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(48), (24), (15), (9), (9), (6), (5), (3), (2), (2), (2)
Pubmed 5 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN650005
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in the N-term of human MALT1 was used as immunogen. This antibody is predicted to detect splice isoform 2 based on sequence analysis.
Alternative Name MALT1 (MLT1)
Background Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5).
Synonyms: MALT1, MLT, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation,Paracaspase
Molecular Weight 92 kDA
Gene ID 10892
UniProt Q9UDY8
Research Area Phospho-specific antibodies, Protein Modifications, Signaling, Chromatin, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500-2000
Comment

Background: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MALT1 (MLT1) Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Dierlamm, Baens, Wlodarska et al.: "The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas." in: Blood, Vol. 93, Issue 11, pp. 3601-9, 1999 (PubMed).

Akagi, Motegi, Tamura et al.: "A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue." in: Oncogene, Vol. 18, Issue 42, pp. 5785-94, 1999 (PubMed).

Uren, ORourke, Aravind et al.: "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma." in: Molecular cell, Vol. 6, Issue 4, pp. 961-7, 2000 (PubMed).

Lucas, Yonezumi, Inohara et al.: "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19012-9, 2001 (PubMed).

Zhou, Wertz, ORourke et al.: "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO." in: Nature, Vol. 427, Issue 6970, pp. 167-71, 2004 (PubMed).

Hosts (56), (9), (2)
Reactivities (65), (25), (19), (11)
Applications (48), (24), (15), (9), (9), (6), (5), (3), (2), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN650005
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top