MAP-2 (pSer136) antibody

Details for Product No. ABIN650006
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Antigen
Synonyms MAP2A, MAP2B, MAP2C, MAP-2, Mtap-2, Mtap2, MAP2R
Epitope
pSer136
(12), (12), (12), (7), (6), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(145), (100), (100), (68), (38), (24), (20), (4), (3), (3), (3), (1)
Host
Rabbit
(96), (84), (17), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(10), (9), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(148), (58), (57), (54), (49), (43), (30), (30), (29), (7), (4), (3), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN650006
Quantity 100 µL
Price
507.14 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A phospho-specific peptide corresponding to residues surrounding Serine 136 of human MAP2 was used as an immunogen.
Alternative Name MAP2
Background Microtubule-associated protein-2 (MAP-2) is a family of heat-stable, phosphoproteins expressed predominantly in the cell body and dendrites of neurons. Three major MAP-2 isoforms, (MAP2a, and MAP2b (280 kDa), MAP2c (75 kDa)) are differentially expressed during the development of the nervous system and have an important role in microtubule dynamics (1). MAP2 is proposed to play important roles in the outgrowth of neuronal processes, synaptic plasticity and neuronal cell death. MAP2 may perform many functions including the nucleation and stabilization of microtubules, the regulation of organelle transport within axons and dendrites, as well as the anchorage of regulatory proteins such as protein kinases which may be important for signal transduction (2). MAP2 is an important cytoskeleton protein whose phosphorylation in response to extracellular signal is involved in the regulation of neurite outgrowth and neuronal plasticity. Findings suggest that epinephrine induces phosphorylation of MAP2c at Serine 136 through an alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neuritis (3).
Molecular Weight 280/75 kDA
Gene ID 4133
UniProt P11137
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-10000
Comment

Background: Microtubule-associated protein-2 (MAP-2) is a family of heat-stable, phosphoproteins expressed predominantly in the cell body and dendrites of neurons. Three major MAP-2 isoforms, (MAP2a, and MAP2b (280 kDa), MAP2c (75 kDa)) are differentially expressed during the development of the nervous system and have an important role in microtubule dynamics (1). MAP2 is proposed to play important roles in the outgrowth of neuronal processes, synaptic plasticity and neuronal cell death. MAP2 may perform many functions including the nucleation and stabilization of microtubules, the regulation of organelle transport within axons and dendrites, as well as the anchorage of regulatory proteins such as protein kinases which may be important for signal transduction (2). MAP2 is an important cytoskeleton protein whose phosphorylation in response to extracellular signal is involved in the regulation of neurite outgrowth and neuronal plasticity. Findings suggest that epinephrine induces phosphorylation of MAP2c at Serine 136 through an alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neuritis (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment MAP2 Antibody Phospho (pS136) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Shafit-Zagardo, Kalcheva: "Making sense of the multiple MAP-2 transcripts and their role in the neuron." in: Molecular neurobiology, Vol. 16, Issue 2, pp. 149-62, 1999 (PubMed).

Sánchez, Díaz-Nido, Avila: "Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function." in: Progress in neurobiology, Vol. 61, Issue 2, pp. 133-68, 2000 (PubMed).

Liu, Saad, Shen et al.: "Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms." in: Advances in anatomic pathology, Vol. 10, Issue 2, pp. 101-6, 2003 (PubMed).

Hosts (96), (84), (17), (1)
Reactivities (145), (100), (100), (68), (38), (24), (20), (4), (3), (3), (3), (1)
Applications (148), (58), (57), (54), (49), (43), (30), (30), (29), (7), (4), (3), (2), (2), (1)
Conjugates (10), (9), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Epitopes (12), (12), (12), (7), (6), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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