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Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) antibody

Antigen

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2)
Synonyms MK2, Rps6kc1, AA960234, mapkapk2, wu:fb30e10, wu:fc56c10, wu:fi03a01, MGC78852, MAPKAPK2
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunoprecipitation (IP)
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN650010
Quantity 100ul
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name MAPKAP Kinase-2
Gene ID 9261
UniProt P49137
Description Other names: MAPKAPK2, MAP kinase-activated protein kinase 2
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues near C-terminus of human MAPKKAP Kinase-2 was used as immunogen.
Molecular Weight 50 kDA
Comments

Background: MAPKAP Kinase-2 is part of mitogen-activated protein (MAP) kinase family which includes MAP kinase kinase kinase (1) and MAP kinase kinase (2). Once activated MAP Kinase-2 will in turn regulate the phosphorylation and activation of many substrates including cell surface molecules, cytoskeletal proteins, transcription factors, and protein kinases (3). MAPKAP Kinase-2 is also known to be a MAP kinase substrate (p38 MAPK ) (4) in addition to phosphorylating low molecular weight heat shock proteins (Hsp27 in humans) and tyrosine hydroxylase.

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:500~1000 IP: ~~ 1:200
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage MAPKAP Kinase-2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Kyriakis, App, Zhang et al.: "Raf-1 activates MAP kinase-kinase." in: Nature, Vol. 358, Issue 6385, pp. 417-21, 1992 (PubMed).

Ahn, Seger, Krebs: "The mitogen-activated protein kinase activator." in: Current opinion in cell biology, Vol. 4, Issue 6, pp. 992-9, 1993 (PubMed).

Rouse, Cohen, Trigon et al.: "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins." in: Cell, Vol. 78, Issue 6, pp. 1027-37, 1994 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2)", type "Antibodies"
Hosts Rabbit (96), Mouse (6)
Reactivities Human (98), Mouse (Murine) (64), Rat (Rattus) (64), Cow (Bovine) (36), Pig (Porcine) (23), Dog (Canine) (13), Chicken (6), Hamster (2), Rabbit (2), Xenopus laevis (1), Zebrafish (Danio rerio) (1)
Applications Western Blotting (WB) (66), Immunofluorescence (IF) (40), ELISA (30), Immunohistochemistry (IHC) (22), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16), Immunoprecipitation (IP) (11), Immunocytochemistry (ICC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Dot Blot (DB) (1), Dot Blot (Dot) (1), Functional Studies (Func) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (4), Alexa Fluor 488 (4), Alexa Fluor 555 (4), Alexa Fluor 647 (4), PE,Cy5.5 (4), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pThr334 (14), pSer272 (7), pThr222 (7), C-Term (5), N-Term (3), Thr334 (3), AA 310-325 (2), AA 344-360 (2), Internal Region (2), Center (1), Thr334,Phosphospecific (1), pSer444 (1), pThr1620, pThr1623 (1)