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Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) antibody
|Synonyms||MK2, Rps6kc1, AA960234, mapkapk2, wu:fb30e10, wu:fc56c10, wu:fi03a01, MGC78852, MAPKAPK2|
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunoprecipitation (IP)
|3 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||MAPKAP Kinase-2|
|Description||Other names: MAPKAPK2, MAP kinase-activated protein kinase 2|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues near C-terminus of human MAPKKAP Kinase-2 was used as immunogen.|
|Molecular Weight||50 kDA|
Background: MAPKAP Kinase-2 is part of mitogen-activated protein (MAP) kinase family which includes MAP kinase kinase kinase (1) and MAP kinase kinase (2). Once activated MAP Kinase-2 will in turn regulate the phosphorylation and activation of many substrates including cell surface molecules, cytoskeletal proteins, transcription factors, and protein kinases (3). MAPKAP Kinase-2 is also known to be a MAP kinase substrate (p38 MAPK ) (4) in addition to phosphorylating low molecular weight heat shock proteins (Hsp27 in humans) and tyrosine hydroxylase.
|Application Notes||The suggested dilution is: WB: ~~ 1:500~1000 IP: ~~ 1:200|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||MAPKAP Kinase-2 Antibody can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Kyriakis, App, Zhang et al.: "Raf-1 activates MAP kinase-kinase." in: Nature, Vol. 358, Issue 6385, pp. 417-21, 1992 (PubMed).
Ahn, Seger, Krebs: "The mitogen-activated protein kinase activator." in: Current opinion in cell biology, Vol. 4, Issue 6, pp. 992-9, 1993 (PubMed).
Rouse, Cohen, Trigon et al.: "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins." in: Cell, Vol. 78, Issue 6, pp. 1027-37, 1994 (PubMed).