Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) antibody

Details for Product No. ABIN650010
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Antigen
Synonyms mapkapk2, wu:fb30e10, wu:fc56c10, wu:fi03a01, MGC78852, MAPKAPK2, AA960234, MAPKAP-K2, MK-2, MK2, Rps6kc1
Reactivity
Human, Rat (Rattus)
(200), (119), (114), (41), (24), (16), (14), (3), (3), (2), (2), (1), (1)
Host
Rabbit
(184), (20), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB)
(164), (90), (89), (30), (30), (25), (23), (11), (9), (6), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 100 μL
Options
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Catalog No. ABIN650010
450.00 $
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Specificity A synthetic peptide corresponding to residues near C-terminus of human MAPKKAP Kinase-2 was used as immunogen.
Alternative Name MAPKAP Kinase-2
Background MAPKAP Kinase-2 is part of mitogen-activated protein (MAP) kinase family which includes MAP kinase kinase kinase (1) and MAP kinase kinase (2). Once activated MAP Kinase-2 will in turn regulate the phosphorylation and activation of many substrates including cell surface molecules, cytoskeletal proteins, transcription factors, and protein kinases (3). MAPKAP Kinase-2 is also known to be a MAP kinase substrate (p38 MAPK ) (4) in addition to phosphorylating low molecular weight heat shock proteins (Hsp27 in humans) and tyrosine hydroxylase.
Synonyms: MAPKAPK2, MAP kinase-activated protein kinase 2
Molecular Weight 50 kDA
Gene ID 9261
UniProt P49137
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500-1000
Comment

Background: MAPKAP Kinase-2 is part of mitogen-activated protein (MAP) kinase family which includes MAP kinase kinase kinase (1) and MAP kinase kinase (2). Once activated MAP Kinase-2 will in turn regulate the phosphorylation and activation of many substrates including cell surface molecules, cytoskeletal proteins, transcription factors, and protein kinases (3). MAPKAP Kinase-2 is also known to be a MAP kinase substrate (p38 MAPK ) (4) in addition to phosphorylating low molecular weight heat shock proteins (Hsp27 in humans) and tyrosine hydroxylase.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MAPKAP Kinase-2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kyriakis, App, Zhang et al.: "Raf-1 activates MAP kinase-kinase." in: Nature, Vol. 358, Issue 6385, pp. 417-21, 1992 (PubMed).

Ahn, Seger, Krebs: "The mitogen-activated protein kinase activator." in: Current opinion in cell biology, Vol. 4, Issue 6, pp. 992-9, 1993 (PubMed).

Rouse, Cohen, Trigon et al.: "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins." in: Cell, Vol. 78, Issue 6, pp. 1027-37, 1994 (PubMed).

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