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Details for Product No. ABIN650010

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) antibody

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Antigen
Synonyms MAPKAP-K2, MK-2, MK2, AA960234, Rps6kc1, mapkapk2, wu:fb30e10, wu:fc56c10, wu:fi03a01, MGC78852, MAPKAPK2
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP)
Pubmed 3 references available
Catalog no. ABIN650010
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues near C-terminus of human MAPKKAP Kinase-2 was used as immunogen.
Alternative Name MAPKAP Kinase-2
Background MAPKAP Kinase-2 is part of mitogen-activated protein (MAP) kinase family which includes MAP kinase kinase kinase (1) and MAP kinase kinase (2). Once activated MAP Kinase-2 will in turn regulate the phosphorylation and activation of many substrates including cell surface molecules, cytoskeletal proteins, transcription factors, and protein kinases (3). MAPKAP Kinase-2 is also known to be a MAP kinase substrate (p38 MAPK ) (4) in addition to phosphorylating low molecular weight heat shock proteins (Hsp27 in humans) and tyrosine hydroxylase.
Synonyms: MAPKAPK2, MAP kinase-activated protein kinase 2
Molecular Weight 50 kDA
Gene ID 9261
UniProt P49137
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:500~1000 IP: ~~ 1:200
Comment

Background: MAPKAP Kinase-2 is part of mitogen-activated protein (MAP) kinase family which includes MAP kinase kinase kinase (1) and MAP kinase kinase (2). Once activated MAP Kinase-2 will in turn regulate the phosphorylation and activation of many substrates including cell surface molecules, cytoskeletal proteins, transcription factors, and protein kinases (3). MAPKAP Kinase-2 is also known to be a MAP kinase substrate (p38 MAPK ) (4) in addition to phosphorylating low molecular weight heat shock proteins (Hsp27 in humans) and tyrosine hydroxylase.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment MAPKAP Kinase-2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kyriakis, App, Zhang et al.: "Raf-1 activates MAP kinase-kinase." in: Nature, Vol. 358, Issue 6385, pp. 417-21, 1992 (PubMed).

Ahn, Seger, Krebs: "The mitogen-activated protein kinase activator." in: Current opinion in cell biology, Vol. 4, Issue 6, pp. 992-9, 1993 (PubMed).

Rouse, Cohen, Trigon et al.: "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins." in: Cell, Vol. 78, Issue 6, pp. 1027-37, 1994 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2)", type "Antibodies"
Hosts (159), (14), (4)
Reactivities (172), (127), (122), (53), (37), (26), (16), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (130), (75), (57), (40), (31), (18), (16), (6), (5), (2), (1), (1), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (34), (26), (20), (18), (6), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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