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Details for Product No. ABIN650018

Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) antibody

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Antigen
Synonyms BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, AW556805, mcl-1
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN650018
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues of human Mcl-1 was used as immunogen. The antibody does not cross-react with other Bcl-2 family members.
Alternative Name Mcl-1
Background Mcl-1 is an anti-apoptotic member of Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway (1). Mcl-1 localizes to the mitochondria (2), interacts with and antagonizes pro-apoptotic Bcl-2 family members (3), and inhibits apoptosis by a number of cytotoxic stimuli (4).
Synonyms: MCL1, BCL2L3, Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-related protein EAT/mcl1,mcl1/EAT,Bcl-2-like protein 3
Molecular Weight 40 kDA
Gene ID 4170
UniProt Q07820
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Protein Modifications, Cell Structure, Cell Cycle
Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:40 ICC: ~~ 1:250~1:500 IHC: ~~ 1:50
Comment

Background: Mcl-1 is an anti-apoptotic member of Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway (1). Mcl-1 localizes to the mitochondria (2), interacts with and antagonizes pro-apoptotic Bcl-2 family members (3), and inhibits apoptosis by a number of cytotoxic stimuli (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Mcl-1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kozopas, Yang, Buchan et al.: "MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3516-20, 1993 (PubMed).

Zhou, Qian, Kozopas et al.: "Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions." in: Blood, Vol. 89, Issue 2, pp. 630-43, 1997 (PubMed).

Alternatives for antigen "Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1)", type "Antibodies"
Hosts (140), (49), (6)
Reactivities (187), (75), (53), (17), (13), (3), (1), (1), (1)
Applications (151), (73), (72), (33), (30), (28), (21), (20), (6), (6), (5), (1), (1)
Conjugates (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (17), (14), (12), (11), (10), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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