C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibody

Details for Product No. ABIN650039
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Antigen
Synonyms C-EYK, MERTK, DKFZp469D2215, si:ch1073-268l12.2, MER, RP38, c-mer, Eyk, Mer, Nyk, nmf12, rdy
Reactivity
Human
(90), (23), (17), (2)
Host
Rabbit
(65), (19), (7), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(73), (45), (22), (11), (10), (6), (5), (4), (2), (2), (1)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN650039
450.00 $
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Specificity A synthetic peptide corresponding to residues near the N-term of human MerTk was used as immunogen.
Alternative Name MerTK
Background MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice, with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).
Synonyms: MERTK, MER, Proto-oncogene tyrosine-protein kinase MER, Receptor tyrosine kinase MerTK
Molecular Weight 180 kDA
Gene ID 10461
UniProt Q12866
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cancer, Signaling, Chromatin, Neurology
Application Notes IHC: = 1:250-500, WB: = 1:1000-10000
Comment

Background: MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice, with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment MerTK Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications DCruz, Yasumura, Weir et al.: "Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat." in: Human molecular genetics, Vol. 9, Issue 4, pp. 645-51, 2000 (PubMed).

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