C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibody
| Antigen |
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| Synonyms |
MER, RP38, c-mer, MGC133349, Eyk, Mer, Nyk, rdy, C-EYK, MERTK, DKFZp469D2215, si:ch1073-268l12.2 |
| Clonality |
Monoclonal |
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Host
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Reactivity
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Conjugate
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)
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| Catalog no. |
ABIN650039 |
| Quantity |
100ul (Variants) |
| Price |
450.00 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Alternative name
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MerTK
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Gene ID
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10461
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UniProt
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Q12866
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Description
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Other names: MERTK, MER, Proto-oncogene tyrosine-protein kinase MER, Receptor tyrosine kinase MerTK
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Characteristics
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Rabbit Monoclonal Antibody
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Specificity
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A synthetic peptide corresponding to residues near the N-term of human MerTk was used as immunogen.
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Molecular Weight
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180 kDA
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Comments
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Background: MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice, with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).
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Application Notes
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The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:50 FC: ~~ 1:40 IHC: ~~ 1:250~500
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Buffer
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50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage
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MerTK Antibody can be stored at -20°C for up to 12 months from time of receipt.
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Research Area
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Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cancer, Signaling, Chromatin, Neurology
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Restrictions
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For Research Use only
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Product
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DCruz, Yasumura, Weir et al.: "Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat." in: Human molecular genetics, Vol. 9, Issue 4, pp. 645-51, 2000 (PubMed).
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Alternatives for antigen "C-Mer Proto-Oncogene Tyrosine Kinase (MERTK)", type "Antibodies"
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Hosts
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Rabbit (33), Mouse (9), Goat (3), Rat (1)
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Reactivities
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Human (42), Mouse (Murine) (19), Rat (Rattus) (18)
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Applications
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Western Blotting (WB) (27), ELISA (17), Immunofluorescence (IF) (16), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunoprecipitation (IP) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (3), Flow Cytometry (FACS) (1), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Epitopes
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N-Term (4), Extracellular Domain (3), AA 50-100 (2), C-Term (2), AA 200-250 (1), AA 746-757 (1), Phosphospecific (1)
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2013 BioMed Central Research Awards
