Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) antibody

Details for Product No. ABIN650063
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Antigen
Synonyms ST3, Stmy3, SL-3, STMY3
Reactivity
Human, Rat (Rattus)
(80), (37), (33), (13), (12), (12), (1)
Host
Rabbit
(70), (20), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(11), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(74), (43), (31), (31), (15), (14), (13), (10), (8)
Pubmed 2 references available
Quantity 100 μL
Options
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Catalog No. ABIN650063
450.00 $
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human MMP-11 was used as an immunogen.
Alternative Name MMP-11
Background The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium, MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3).
Synonyms: MMP11, STMY3, Stromelysin-3, Matrix metalloproteinase-11
Molecular Weight 58/45 (latent/active forms) kDA
Gene ID 4320
UniProt P24347
Research Area Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500 , IHC: = 1:100-250
Comment

Background: The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium, MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment MMP-11 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Matrisian: "Metalloproteinases and their inhibitors in matrix remodeling." in: Trends in genetics : TIG, Vol. 6, Issue 4, pp. 121-5, 1992 (PubMed).

Pei, Weiss: "Furin-dependent intracellular activation of the human stromelysin-3 zymogen." in: Nature, Vol. 375, Issue 6528, pp. 244-7, 1995 (PubMed).

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