Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11) antibody

Antigen: Matrix Metallopeptidase 11 (Stromelysin 3) (MMP11)

Synonyms: ST3, SL-3, STMY3

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Certificates: ISO 9001:2008

Catalog no.: ABIN650063

Additional Information

Alternative name: MMP-11

Gene ID: 4320

UniProt: P24347

Description: Other names: MMP11, STMY3, Stromelysin-3, Matrix metalloproteinase-11

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues near the C-terminus of human MMP-11 was used as an immunogen.

Molecular Weight: 58/45 (latent/active forms) kDA

Comments:

Background: The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium, MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:500 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: MMP-11 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Cell Signaling, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Publications

Product: Matrisian: "Metalloproteinases and their inhibitors in matrix remodeling." in: Trends in genetics : TIG, Vol. 6, Issue 4, pp. 121-5, 1992 (PubMed).

Pei, Weiss: "Furin-dependent intracellular activation of the human stromelysin-3 zymogen." in: Nature, Vol. 375, Issue 6528, pp. 244-7, 1995 (PubMed).