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Details for Product No. ABIN650083

MRP14/S100-A9 antibody

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Antigen
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Pubmed 3 references available
Catalog no. ABIN650083
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in human MRP14/S100-A9 was used as an immunogen.
Background S100-A9 (MRP14) is a member of the S100 family proteins containing two EF-hand calcium-binding motifs (1). S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation (2). S100-A9 forms a heterodimer, Calprotectin, with S100-A8 in a calcium-dependent manner. Calprotectin is a major calcuim- and zinc-binding protein in the cytosol of neutrophils, monocytes, and keratinocytes (3). S100-A9 may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis (2).
Synonyms: S100A9, CAGB, CFAG, MRP14, Protein S100-A9, Leukocyte L1 complex heavy chain,Calprotectin L1H subunit
Molecular Weight 14 kDA
Gene ID 928
UniProt P06702
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~5000 ICC: ~~ 1:100~250 IHC: ~~ 1:250~500
Comment

Background: S100-A9 (MRP14) is a member of the S100 family proteins containing two EF-hand calcium-binding motifs (1). S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation (2). S100-A9 forms a heterodimer, Calprotectin, with S100-A8 in a calcium-dependent manner. Calprotectin is a major calcuim- and zinc-binding protein in the cytosol of neutrophils, monocytes, and keratinocytes (3). S100-A9 may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment MRP14/S100-A9 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Hunter, Chazin: "High level expression and dimer characterization of the S100 EF-hand proteins, migration inhibitory factor-related proteins 8 and 14." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12427-35, 1998 (PubMed).

Sampson, Fagerhol, Sunderkötter et al.: "Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism." in: Lancet, Vol. 360, Issue 9347, pp. 1742-5, 2002 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Alternatives for antigen "MRP14/S100-A9", type "Antibodies"
Hosts (1)
Reactivities (1)
Applications (1), (1)
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