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Details for Product No. ABIN650107

TANK-Binding Kinase 1 (TBK1) (N-Term) antibody

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Antigen
Synonyms NAK, T2K, 1200008B05Rik, AI462036, AW048562, nak, t2k, TBK1, wu:fk70c05, zgc:136548
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN650107
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in the N-term of human NAK was used as immunogen.
Alternative Name NAK/TBK1
Background NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−,associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).
Synonyms: TBK1, NAK, Serine/threonine-protein kinase TBK1, TANK-binding kinase 1,T2K,NF-kappa-B-activating kinase
Molecular Weight 84 kDA
Gene ID 29110
UniProt Q9UHD2
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:2000 IP: ~~ 1:30 FC: ~~ 1:50 ICC: ~~ 1:250~500 IHC: ~~ 1:50
Comment

Background: NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−,associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment NAK/TBK1 Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Pomerantz, Baltimore: "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase." in: The EMBO journal, Vol. 18, Issue 23, pp. 6694-704, 2000 (PubMed).

Alternatives for antigen "TANK-Binding Kinase 1 (TBK1)", type "Antibodies"
Hosts (62), (13), (1)
Reactivities (64), (37), (24), (19), (19), (12)
Applications (57), (21), (16), (11), (10), (7), (5), (4), (3), (1), (1), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (13), (7), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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