Neurofilament L (C-Term) antibody

Details for Product No. ABIN650115
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Antigen
Epitope
C-Term
(2), (1)
Reactivity
Human, Rat (Rattus)
(4), (2), (2)
Host
Rabbit
(4), (1)
Clonality
Monoclonal
Application
Western Blotting (WB)
(5), (3), (3), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN650115
450.00 $
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Specificity A synthetic peptide corresponding to residues near the C-term of human NF-L was used as immunogen.
Background Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins, NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). NF-L self polymerizes and provides a scaffold for NFs to form via cross-bridging with NF-H or NF-M (3). NF-L aggregation has been linked to the pathogenesis of neurodegenerative disease, such as degradation of motor neurons (4).
Synonyms: NEFM, NEF3, NFM, Neurofilament medium polypeptide, Neurofilament triplet M protein,160 kDa neurofilament protein,Neurofilament 3
Molecular Weight 68 kDA
Gene ID 4747
UniProt P07196
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Neurology, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000
Comment

Background: Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins, NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). NF-L self polymerizes and provides a scaffold for NFs to form via cross-bridging with NF-H or NF-M (3). NF-L aggregation has been linked to the pathogenesis of neurodegenerative disease, such as degradation of motor neurons (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Neurofilament L Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Julien, Meyer, Flavell et al.: "Cloning and developmental expression of the murine neurofilament gene family." in: Brain research, Vol. 387, Issue 3, pp. 243-50, 1987 (PubMed).

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