Neurofilament Triplet M Protein (NEFM) antibody

Details for Product No. ABIN650116
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Antigen
Synonyms NEF3, NF-M, Nef3, Nfm, NF160, NF165, NFM, nef-m, nef3, nefm, nf-m
Reactivity
Human
(70), (60), (29), (24), (21), (11), (6), (4), (3), (3), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(56), (45), (18), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(104), (42), (39), (26), (23), (23), (21), (10), (10), (8), (7), (4), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Request Want additional data for this product?

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Catalog No. ABIN650116
450.00 $
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Specificity A synthetic peptide corresponding to residues in human Neurofilament M was used as an immunogen.
Alternative Name Neurofilament M
Background Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins, NF-H, NF-M and NF-L and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2).
Synonyms: NEFM, NEF3, NFM, Neurofilament medium polypeptide, Neurofilament triplet M protein,160 kDa neurofilament protein,Neurofilament 3
Molecular Weight 160 kDA
Gene ID 6291
UniProt P07197
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000 , IHC: = 1:250-500
Comment

Background: Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins, NF-H, NF-M and NF-L and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Neurofilament M Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Nixon, Shea: "Dynamics of neuronal intermediate filaments: a developmental perspective." in: Cell motility and the cytoskeleton, Vol. 22, Issue 2, pp. 81-91, 1992 (PubMed).

Julien, Meyer, Flavell et al.: "Cloning and developmental expression of the murine neurofilament gene family." in: Brain research, Vol. 387, Issue 3, pp. 243-50, 1987 (PubMed).

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