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Details for Product No. ABIN650117

Neurofilament Triplet M Protein (NEFM) (pSer614), (pSer619) antibody

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Antigen
Synonyms NFM, NEF3, NF-M, Nfm, Nef3, NF160, NF165
Epitope
»Alternatives pSer614, pSer619
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN650117
Quantity 100 µL
Price
507.14 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic phospho-peptide corresponding to residues surrounding Serine 614/619 of human NF-M was used as an immunogen.
Alternative Name Neurofilament M
Background Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins, NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). Several phsopholyation sites have been discovered on NF-M, including serine 614 and 619. However, their specific implication on NF-M function has not been identified.
Synonyms: NEFM, NEF3, NFM, Neurofilament medium polypeptide, Neurofilament triplet M protein,160 kDa neurofilament protein,Neurofilament 3
Molecular Weight 160 kDA
Gene ID 4741
UniProt P07197
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:500 IP: ~~ 1:30 IHC: ~~ 1:100~250
Comment

Background: Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins, NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). Several phsopholyation sites have been discovered on NF-M, including serine 614 and 619. However, their specific implication on NF-M function has not been identified.

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Neurofilament M Antibody Phospho (pS614/619) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Julien, Meyer, Flavell et al.: "Cloning and developmental expression of the murine neurofilament gene family." in: Brain research, Vol. 387, Issue 3, pp. 243-50, 1987 (PubMed).

Alternatives for antigen "Neurofilament Triplet M Protein (NEFM)", type "Antibodies"
Hosts (38), (32), (12), (2)
Reactivities (49), (46), (24), (19), (17), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (70), (22), (22), (19), (16), (14), (13), (10), (7), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (6), (3), (1), (1)
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