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Details for Product No. ABIN650120

Neuropilin 1 (NRP1) antibody

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Antigen
Synonyms BDCA4, CD304, NP1, NRP, VEGF165R, Nrp, NP-1, Npn1, NPN-1, C530029I03, neuropilin, np-1, npn-1, nrp, nrp-1, NRP1, cd304, vegf165r
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN650120
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in the cytoplasmic region of human Neuropilin-1 was used as an immunogen.
Alternative Name Neuropilin-1
Background Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neurophilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. NP-1 isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis and in the formation of certain neuronal circuits and in organogenesis outside the nervous system (1). The soluble NP-1 isoform 2 binds VEGF(165) and appears to inhibit its binding to cells (2). It may also induce apoptosis by sequestering VEGF(165). NP-1 may bind various members of the semaphorin family. Its expression has an adverse effect on blood vessel number and integrity (3).
Synonyms: PKM2, PK2, PK3, PKM, Pyruvate kinase isozymes M1/M2, THBP1,p58,M2-PK,Tumor M2-PK
Molecular Weight 130 kDA
Gene ID 8829
UniProt O14786
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Neurology
Application Notes The suggested dilution is: WB: ~~ 1:1000 IP: ~~ 1:50 FC: ~~ 1:100 IHC: ~~ 1:100
Comment

Background: Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neurophilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. NP-1 isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis and in the formation of certain neuronal circuits and in organogenesis outside the nervous system (1). The soluble NP-1 isoform 2 binds VEGF(165) and appears to inhibit its binding to cells (2). It may also induce apoptosis by sequestering VEGF(165). NP-1 may bind various members of the semaphorin family. Its expression has an adverse effect on blood vessel number and integrity (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Neuropilin-1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Gluzman-Poltorak, Cohen, Herzog et al.: "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]." in: The Journal of biological chemistry, Vol. 275, Issue 24, pp. 18040-5, 2000 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Alternatives for antigen "Neuropilin 1 (NRP1)", type "Antibodies"
Hosts (66), (7), (5), (1)
Reactivities (58), (33), (29), (12), (12)
Applications (50), (30), (20), (20), (15), (14), (9), (6), (4), (1), (1)
Conjugates (8), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (12), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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