Neuropilin 1 (NRP1) antibody
| Antigen | Neuropilin 1 (NRP1) |
| Synonyms | NP1, NRP, BDCA4, CD304, VEGF165R, DKFZp781F1414, DKFZp686A03134, Nrp, NP-1, Npn1, NPN-1, C530029I03, NRP1, nrp, np-1, cd304, npn-1, vegf165r, DKFZp468P0513, DKFZp468P0819, DKFZp469C0311 |
| Clonality | Monoclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus) |
| Conjugate |
Alternatives Un-conjugated |
| Application |
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP) |
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2 references available |
| Certificates | ISO 9001:2008 |
| Catalog no. | ABIN650120 |
| Quantity | 100ul |
| Price | 450.00 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 2 to 3 Business Days |
Additional Information
| Alternative name | Neuropilin-1 |
| Gene ID | 8829 |
| UniProt | O14786 |
| Description | Other names: PKM2, PK2, PK3, PKM, Pyruvate kinase isozymes M1/M2, THBP1,p58,M2-PK,Tumor M2-PK |
| Characteristics | Rabbit Monoclonal Antibody |
| Specificity | A synthetic peptide corresponding to residues in the cytoplasmic region of human Neuropilin-1 was used as an immunogen. |
| Molecular Weight | 130 kDA |
| Comments |
Background: Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neurophilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. NP-1 isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis and in the formation of certain neuronal circuits and in organogenesis outside the nervous system (1). The soluble NP-1 isoform 2 binds VEGF(165) and appears to inhibit its binding to cells (2). It may also induce apoptosis by sequestering VEGF(165). NP-1 may bind various members of the semaphorin family. Its expression has an adverse effect on blood vessel number and integrity (3). |
Application Details
| Application Notes | The suggested dilution is: WB: ~~ 1:1000 IP: ~~ 1:50 FC: ~~ 1:100 IHC: ~~ 1:100 |
| Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Neuropilin-1 Antibody can be stored at -20°C for up to 12 months from time of receipt. |
| Research Area | Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Neurology |
| Restrictions | For Research Use only |
Publications
| Product |
Gluzman-Poltorak, Cohen, Herzog et al.: "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]." in: The Journal of biological chemistry, Vol. 275, Issue 24, pp. 18040-5, 2000 (PubMed).
"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed). |
Alternatives
| Hosts | Rabbit (54), Mouse (8), Goat (3) |
| Reactivities | Human (50), Rat (Rattus) (31), Mouse (Murine) (28), Chicken (19), Sheep (Ovine) (18), Dog (Canine) (6), Cow (Bovine) (2), Cat (Feline) (1), Pig (Porcine) (1), Rabbit (1) |
| Applications | Western Blotting (WB) (39), ELISA (27), Immunofluorescence (IF) (26), Immunohistochemistry (IHC) (18), Immunocytochemistry (ICC) (5), Flow Cytometry (FACS) (4), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Blocking Antibody (Inhibition) (1), Immunoelectron Microscopy (IEM) (1) |
| Conjugates | Biotin (4), FITC (3), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE (2), PE,Cy5.5 (2), APC (1), CF (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1) |
| Epitopes | pThr916 (4), N-Term (3), C-Term (2), Extracellular Domain (2), AA 22-644 (1), AA 813-827 (1) |
2013 BioMed Central Research Awards
