Stathmin 1 (STMN1) (pSer24) antibody

Details for Product No. ABIN650156
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Antigen
Synonyms
op18, stathmin, stmn1, stmn1a, lag, lap18, pp17, pp19, pr22, smn, fj43c10, wu:fj38b07, wu:fj43c10, zgc:110159, cb959, wu:fb14e04, zgc:136942, LOC100217988, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22 ... show more
op18, stathmin, stmn1, stmn1a, lag, lap18, pp17, pp19, pr22, smn, fj43c10, wu:fj38b07, wu:fj43c10, zgc:110159, cb959, wu:fb14e04, zgc:136942, LOC100217988, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, 19k, Lap18, Op18, P18, P19, Pig, Pp17, Pp18, Pp19, Pr22, Smn, prosolin show less
Epitope
pSer24
(30), (25), (24), (22), (19), (18), (17), (17), (15), (14), (14), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(322), (221), (199), (36), (25), (3), (1)
Host
Rabbit
(314), (6), (6)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1)
Application
Western Blotting (WB)
(255), (165), (100), (95), (52), (50), (33), (22), (17), (8), (4), (2), (1)
Pubmed 3 references available
Quantity 100 μL
Options
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Catalog No. ABIN650156
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Specificity A phospho specific peptide corresponding to residues surrounding Serine 24 of human Op18 was used as an immunogen. This antibody detects Op18 phosphorylated at Serine 24.
Alternative Name Op18
Background Oncoprotein 18 (Op18) is a proliferation-related cytosolic phosphoprotein which is induced in normal lymphocytes following mitogenic stimulation. Studies of Op18 are of particular interest because of the proposed role it plays in signal transduction and because of its occurrence in markedly increased amounts in acute leukemia cells (1). Oncoprotein 18 has been independently identified due to its increased phosphorylation in response to external signals and its up-regulated expression in acute leukemia. Findings suggest that Op18 may be a physiological substrate for several members of the cdc2 kinase family during both the S-phase and the mitotic phase of the cell cycle (2). Also, findings show that Op18 by itself can fold into a flexible and extended alpha-helix, which is in equilibrium with a less ordered structure. In complex with tubulin, however, all except the last seven C-terminal residues of Op18 are tightly bound to tubulin. Studies suggest results suggest that besides sequestering tubulin, the structural features of Op18 enable the protein specifically to recognize microtubule ends to trigger catastrophes (3).
Synonyms: STMN1, LAP18, OP18, Stathmin, pp17,Prosolin,Metablastin,Protein Pr22
Molecular Weight 19 kDA
Gene ID 3925
UniProt P16949
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Neurology, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500-1000
Comment

Background: Oncoprotein 18 (Op18) is a proliferation-related cytosolic phosphoprotein which is induced in normal lymphocytes following mitogenic stimulation. Studies of Op18 are of particular interest because of the proposed role it plays in signal transduction and because of its occurrence in markedly increased amounts in acute leukemia cells (1). Oncoprotein 18 has been independently identified due to its increased phosphorylation in response to external signals and its up-regulated expression in acute leukemia. Findings suggest that Op18 may be a physiological substrate for several members of the cdc2 kinase family during both the S-phase and the mitotic phase of the cell cycle (2). Also, findings show that Op18 by itself can fold into a flexible and extended alpha-helix, which is in equilibrium with a less ordered structure. In complex with tubulin, however, all except the last seven C-terminal residues of Op18 are tightly bound to tubulin. Studies suggest results suggest that besides sequestering tubulin, the structural features of Op18 enable the protein specifically to recognize microtubule ends to trigger catastrophes (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Op18 Antibody Phospho (pS24) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Melhem, Zhu, Hailat et al.: "Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia." in: The Journal of biological chemistry, Vol. 266, Issue 27, pp. 17747-53, 1991 (PubMed).

Brattsand, Marklund, Nylander et al.: "Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38." in: European journal of biochemistry / FEBS, Vol. 220, Issue 2, pp. 359-68, 1994 (PubMed).

Steinmetz, Kammerer, Jahnke et al.: "Op18/stathmin caps a kinked protofilament-like tubulin tetramer." in: The EMBO journal, Vol. 19, Issue 4, pp. 572-80, 2000 (PubMed).

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